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Dear fellow neuroscientists, Please join us on Tuesday, February 21 at 1:00 pm EST (UTC-5) for the next edition of E.A.R.S. (Electronic Auditory Research Seminars), a monthly auditory
seminar series focused on central auditory processing and circuits. Speakers: Sam Norman-Haignere (University
of Rochester): "Neural integration in the human auditory cortex" To derive meaning from sound, the brain must integrate information across many timescales spanning tens (e.g., phonemes)
to hundreds (e.g., words) of milliseconds. Yet, identifying the integration timescales of auditory neural populations has been challenging, in part due to their complex, nonlinear tuning for natural sound structure. In this talk, I will describe a new method
to estimate neural integration windows using natural stimuli (the temporal context invariance paradigm). Our method is conceptually simple and general, and thus applicable to virtually any brain region, sensory domain, or temporally precise recording modality.
By applying this method to intracranial recordings from human neurosurgical patients, we have found that the human auditory cortex integrates hierarchically across diverse timescales spanning approximately 50 to 400 ms, with substantially longer integration
windows in non-primary regions, bilaterally. Moreover, we have found that neural populations with short and long integration windows exhibit distinct functional properties: short-integration electrodes (less than ~200 ms) show prominent spectrotemporal modulation
selectivity, while long-integration electrodes (greater than ~200 ms) show prominent category selectivity. These findings reveal how multiscale integration organizes auditory computation in the human brain. Ross Williamson (University
of Pittsburgh): "Brain-wide neural circuits for sensory-guided behavior" Auditory-guided behavior is ubiquitous in everyday life, whenever auditory information is used to guide the
decisions we make and the actions we take. One such behavior is auditory categorization, a process that reflects the ability to transform bottom-up sensory stimuli into discrete perceptual categories and use these perceptual categories to drive a subsequent
action. Although this process is well-documented at the behavioral and cognitive levels, surprisingly little is known about the explicit neural circuit mechanisms that underlie categorical computation and how the result of this computation drives behavioral
outcomes. We believe that the transformation of auditory information into an appropriate behavioral response is necessarily a brain-wide endeavor. The deep layers of the auditory cortex give rise to several massive projection systems that exert influence over
many downstream brain areas. Here,
I will discuss our efforts towards understanding how these distinct systems differentially contribute to auditory-guided behavior. The seminar will be hosted on Zoom. You can access the seminars here: https://pennmedicine.zoom.us/j/95396120820.
This link is also posted on our website https://sites.google.com/view/ears2020/home.
The E.A.R.S. subscriber list is the ears-seminar google group, which you can join by emailing: ears2022+subscribe@xxxxxxxxxxxxxxxx or visiting
the following link: https://groups.google.com/g/ears2022. Additional upcoming E.A.R.S. seminars (1:00 pm ET):
With kind wishes, Maria Geffen Yale Cohen Steve Eliades Stephen David Alexandria Lesicko Nathan Vogler Jean-Hugues Lestang Huaizhen Cai |