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Dear
colleagues, Nicolas
Michalski and Boris Gourévitch of the PCAC lab (Plasticity
of Central auditory Cirtuis) are proposing a PhD within the
framework of the Institut Pasteur international PhD call.
The objective of the Pasteur-Paris University
International Doctoral Program is to train promising young
scientists in Life Sciences and Biomedicine for 3 years PhD
program for students holding Please find below the
title and an abstract of our
AUDIOLOUD proposal : Title : Loud sound intensity processing by
the auditory nerve in health and disease (Neuroscience, cochea, sound intensity,
electrophysiology, genetics): One key component of the
auditory system allowing the large working range for intensity processing are the afferent
primary sensory neurons of the auditory nerve. High threshold
fibers of the auditory nerve, which detect and process loud
sounds have been shown to be more sensitive to ageing and
noise exposure, potentially explaining speech comprehension
difficulties in elderly people and people exposed chronically
to loud sounds/noise. Despite these key roles, little is known
about their functioning and the pathophysiological mechanisms
in which they are involved. One major limitation until now has
been the lack of genetic tools to trace and manipulate these
fibers. Using new mouse genetic tools the hosting lab
developed, the goal of the PhD will be to gain insight into
the functioning of high threshold fibers and to decipher the
pathophysiological mechanisms to which they are associated,
using a combination of approaches including electrophysiology,
auditory perception paradigms, and histology. A few words about the
lab and the Institut de L’audition in Paris: During his career, the
supervisor has been addressing how sound information is transduced, encoded, transmitted,
and processed with extreme temporal precision along the
auditory pathways. He established in 2019 a research team
entitled « Plasticity of Central Auditory Circuits » dedicated
to deciphering the molecular pathways regulating the
connectivity and functioning of the central auditory pathways. Websites : https://research.pasteur.fr/en/team/plasticity-of-central-auditory-circuits/ |