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Dear All, I am delighted to confirm our next speaker in the Hearing Sciences Seminar Series is Professor Dan Jagger, a Professor in Cell Physiology at the UCL Ear Institute, who will be giving the following talk (@2pm on Thursday the 24th
of February): “Roles for inner ear connexins in health and disease” Abstract:
The normal development, function and repair of inner ear sensory epithelia are dependent on gap junctional communication. Gap junctions are intercellular membrane channels connecting adjacent
cells and are constructed from connexin protein subunits. Connexin 26 (Cx26) and Cx30 are widely expressed in the epithelial and connective tissues of the cochlea, where they may form homomeric or heteromeric gap junction channels in a cell-specific and spatiotemporally
complex fashion. Mutations in the connexin genes GJB2 and GJB6 (encoding Cx26 and Cx30) result in syndromic and non-syndromic deafness via various mechanisms. In this seminar I will review the proposed roles for gap junctions in normal auditory function, and
our current understanding of how connexin mutations result in hearing loss.
Biography:
Dan Jagger is Professor of Cell Physiology at the UCL Ear Institute. Following a BSc at the University of Newcastle Upon Tyne he completed his PhD in Jonathan Ashmore’s lab at the University
of Bristol. Following postdocs at UCL and the University of Auckland he held a Royal Society University Research Fellowship at the UCL Ear Institute (2003-2011), and has remained there since. His lab currently studies questions of inner ear homeostasis, neuronal
signalling, and hair cell development. Best wishes, Joe ________________________________________________________________________________
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here to join the meeting Dr Joseph Sollini Auditory Circuits Lab Hearing Sciences Mental Health and Clinical Neuroscience, School of Medicine The University of Nottingham W:
https://www.nottingham.ac.uk/research/groups/hearingsciences/people/joseph.sollini W:
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