[AUDITORY] Nottingham Hearing Sciences Seminar Series: Sunil Puria (Tim Beechey )

Subject: [AUDITORY] Nottingham Hearing Sciences Seminar Series: Sunil Puria From: Tim Beechey <00000252113a4de3-dmarc-request@xxxxxxxx> Date: Fri, 25 Aug 2023 09:51:14 +0000 --_000_AM6PR06MB6232636B48D84D3F741F522ECAE3AAM6PR06MB6232eurp_ Content-Type: text/plain; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Hi all, We are very happy to announce Assoc. Prof. Sunil Puria (Department of Otola= ryngology, Harvard Medical School and Massachusetts Eye and Ear) will be sp= eaking on =93Measurements of Cochlear amplification, compression and transd= uction=94 at 2pm (UK time) on the 31st of August. The seminar will be held = over MS Teams. Click here to join the meeting<https://teams.microsoft.com/l/meetup-join/19= %3ameeting_Mjg4NGZjMDEtMDE3NC00NDg2LTkwMDAtODQ5Y2U4MjdhMDZk%40thread.v2/0?c= ontext=3D%7b%22Tid%22%3a%2267bda7ee-fd80-41ef-ac91-358418290a1e%22%2c%22Oid= %22%3a%226ea8aa20-734a-4feb-8e47-1017e90351f2%22%7d> Speaker bio Sunil Puria is Associate Professor in the Department of Otolaryngology, Har= vard Medical School, and Amelia-Peabody Scientist at Massachusetts Eye and = Ear. He studies the biomechanics of the middle ear and cochlea using imagin= g modalities such as optical coherence tomography (OCT) and uCT and physiol= ogy using laser 3D Doppler vibrometers that are incorporated into finite el= ement models. Abstract Throughout history, our understanding of cochlear amplification, compressio= n and transduction mechanisms has gone through major changes. The ter Kuile= model (1900) has been the standard for converting basilar membrane (BM) mo= tion to hair cell transduction. Bekesy (1947) formulated the travelling wav= e, but all based on passive mechanics in cadaver ears. Rhode (1971) changed= all that when he showed in vivo compressive non-linearity of the BM. Brown= ell=92s (1985) measurements indicated that the site of the non-linearity an= d sensitive hearing are the beautifully arranged three rows outer hair cell= s (OHCs). Reticular lamina (RL) motion has recently been shown to move more= than the BM. Our knowledge of cochlear organ-of-Corti mechanics is once ag= ain undergoing another major rethinking. Much of this is being heralded by = the advent of optical coherence tomography (OCT) which allows displacement = measurements with Angstrom level resolution. Our measurements in the gerbil= high-frequency basal region reveal that the RL at OHC row 3 moves signific= antly more than at OHC row 1. This new discovery suggests that the RL=92s m= osaic structure is not stiff, but rather bends and/or stretches and questio= ns the prevailing ter Kuile model for transduction. This has implications f= or transduction in the human and mouse cochlea which we also measure using = OCT. Timothy Beechey Medical Research Foundation Fellow Hearing Sciences =96 Scottish Section, Mental Health and Clinical Neurosciences, School of Medicine University of Nottingham New Lister Building Level 3, Glasgow Royal Infirmary, 10-16 Alexandra Parade, Glasgow G31 2ER This message and any attachment are intended solely for the addressee and m= ay contain confidential information. If you have received this message in e= rror, please contact the sender and delete the email and attachment. Any vi= ews or opinions expressed by the author of this email do not necessarily re= flect the views of the University of Nottingham. Email communications with = the University of Nottingham may be monitored where permitted by law. --_000_AM6PR06MB6232636B48D84D3F741F522ECAE3AAM6PR06MB6232eurp_ Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable <html xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:w=3D"urn:sc= hemas-microsoft-com:office:word" xmlns:m=3D"http://schemas.microsoft.com/of= fice/2004/12/omml" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3D"Content-Type" content=3D"text/html; charset=3DWindows-1= 252"> <meta name=3D"Generator" content=3D"Microsoft Word 15 (filtered medium)"> <style></style> </head> <body lang=3D"EN-GB" link=3D"#0563C1" vlink=3D"#954F72" style=3D"word-wrap:= break-word"> <div class=3D"WordSection1"> Hi all,<o:p></o:p> <o:p> </o:p> We are very happy to announce Assoc. Prof. Sunil = Puria (Department of Otolaryngology, Harvard Medical School and Massach= usetts Eye and Ear) will be speaking on =93Measurements of Cochlear ampl= ification, compression and transduction=94 at 2pm (UK time) on the 31st of August. The seminar will be held ov= er MS Teams.<o:p></o:p> <o:p> </o:p> <a href=3D"https://teams.microsoft.com/l/meetup-join= /19%3ameeting_Mjg4NGZjMDEtMDE3NC00NDg2LTkwMDAtODQ5Y2U4MjdhMDZk%40thread.v2/= 0?context=3D%7b%22Tid%22%3a%2267bda7ee-fd80-41ef-ac91-358418290a1e%22%2c%22= Oid%22%3a%226ea8aa20-734a-4feb-8e47-1017e90351f2%22%7d" title=3D"https://te= ams.microsoft.com/l/meetup-join/19%3ameeting_Mjg4NGZjMDEtMDE3NC00NDg2LTkwMD= AtODQ5Y2U4MjdhMDZk%40thread.v2/0?context=3D%7b%22Tid%22%3a%2267bda7ee-fd80-= 41ef-ac91-358418290a1e%22%2c%22Oid%22%3a%226ea8aa20-734a-4feb-8e47-1017e903= 51f2%22%7d">Click here to join the meeting</a><o:p></o:p> <o:p> </o:p> Speaker bio<o:p></o:p> Sunil Puria is Associate Professor in the Department= of Otolaryngology, Harvard Medical School, and Amelia-Peabody Scientist at= Massachusetts Eye and Ear. He studies the biomechanics of the middle ear a= nd cochlea using imaging modalities such as optical coherence tomography (OCT) and uCT and physiology using la= ser 3D Doppler vibrometers that are incorporated into finite element models= .<o:p></o:p> <o:p> </o:p> Abstract<o:p></o:p> Throughout history, our understanding of cochlear am= plification, compression and transduction mechanisms has gone through major= changes. The ter Kuile model (1900) has been the standard for converting b= asilar membrane (BM) motion to hair cell transduction. Bekesy (1947) formulated the travelling wave, but all b= ased on passive mechanics in cadaver ears. Rhode (1971) changed all that wh= en he showed in vivo compressive non-linearity of the BM. Brownell=92s (198= 5) measurements indicated that the site of the non-linearity and sensitive hearing are the beautifully arrang= ed three rows outer hair cells (OHCs). Reticular lamina (RL) motion has rec= ently been shown to move more than the BM. Our knowledge of cochlear organ-= of-Corti mechanics is once again undergoing another major rethinking. Much of this is being heralded by the= advent of optical coherence tomography (OCT) which allows displacement mea= surements with Angstrom level resolution. Our measurements in the gerbil hi= gh-frequency basal region reveal that the RL at OHC row 3 moves significantly more than at OHC row 1. This = new discovery suggests that the RL=92s mosaic structure is not stiff, but r= ather bends and/or stretches and questions the prevailing ter Kuile model f= or transduction. This has implications for transduction in the human and mouse cochlea which we also measure usin= g OCT.<o:p></o:p> <o:p> </o:p> <div> <div> Timothy= Beechey Medical Research Fo= undation Fellow<o:p></o:p> </div> Hearing Sciences =96 Scottish Section, <o:p></o:p> Mental Health and Clinical Neurosciences, School of Medicine<o:p></o:= p> University of Nottingham New Lister= Building Level 3, Glasgow Royal Infirmary,  10-16 Alexandra Parade, Glasgow G31 2ER<o:p></o:p> <o:p> </o:p> </div> <o:p> </o:p> </div> This message and any attachment are intended solely for the addressee and m= ay contain confidential information. If you have received this message in e= rror, please contact the sender and delete the email and attachment. Any vi= ews or opinions expressed by the author of this email do not necessarily reflect the views of the Universit= y of Nottingham. Email communications with the University of Nottingham may= be monitored where permitted by law. </body> </html> --_000_AM6PR06MB6232636B48D84D3F741F522ECAE3AAM6PR06MB6232eurp_--

This message came from the mail archive
postings/2023/
maintained by:

DAn Ellis <dpwe@ee.columbia.edu>
Electrical Engineering Dept., Columbia University