[AUDITORY] Seminar Announcement - May 9 - E.A.R.S. (Electronic Auditory Research Seminars) ("Vogler, Nathan" )

Subject: [AUDITORY] Seminar Announcement - May 9 - E.A.R.S. (Electronic Auditory Research Seminars) From: "Vogler, Nathan" <Nathan.Vogler@xxxxxxxx> Date: Mon, 8 May 2023 15:59:34 +0000 --_000_MN2PR04MB6127CBA576F2650C4D0C6F11C8719MN2PR04MB6127namp_ Content-Type: text/plain; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Dear fellow neuroscientists, Please join us Tomorrow, May 9 at 1:00 pm EDT (UTC-4) for the next edition = of E.A.R.S. (Electronic Auditory Research Seminars), a monthly auditory sem= inar series focused on central auditory processing and circuits. Speakers: Charles Anderson (West Virginia University): "Cell-type specific enhancemen= t of deviance detection by synaptic zinc in mouse auditory cortex=94 A fundamental feature of sensory processing is the ability of animals to ad= apt to the current conditions in their the environment yet maintain their a= bility to detect novelty in the same environment. A correlate of this abili= ty is a robust neuronal phenomenon called stimulus-specific adaptation, in = which a repeated stimulus will result in smaller and smaller neuronal respo= nses over time, but a deviant stimulus will still elicit robust responses f= rom the same neurons. Recent work has established that synaptically release= d zinc is an endogenous mechanism that shapes neuronal responses to sounds = in the auditory cortex. Here, to understand the contributions of cortical s= ynaptic zinc to deviance detection of specific cortical neurons we performe= d wide field and 2-photon calcium imaging of multiple classes of cortical g= lutamatergic neurons. We find that intratelencephalic (IT) neurons in both = layer 2/3 and layer 5 as well as extratelencephalic (ET) neurons in layer 5= all demonstrate deviance detection, however, we find a specific enhancemen= t of this deviance detection in ET neurons that arises from ZnT3-dependent = synaptic zinc in layer 2/3 IT neurons. Genetic deletion of ZnT3 from layer = 2/3 IT neurons removes the enhancing effects of synaptic zinc on ET neuron = deviance detection and also results in poorer acuity of detecting deviant s= ounds by behaving mice. Dayo Adewole (University of Pennsylvania): "Tissue Engineering for Auditory= Rehabilitation" Sensorineural hearing loss (SHL) affects an estimated 18% of the human popu= lation, with the World Health Organization projecting one in ten people wit= h =91disabling=92 hearing loss by 2050. SHL occurs when cells within the au= ditory pathway degenerate or die (as a result of injury, disease, or aging)= and is historically considered irreversible. Current clinical intervention= s to restore a degree of hearing following SHL use implantable devices that= deliver electrical impulses to activate the user=92s surviving auditory pa= thway (e.g.cochlear implants); ongoing challenges for these "auditory neuro= prosthetics" include recreating complex sounds due to limited tonotopic res= olution & maintaining performance over time as the auditory pathway degener= ates. Advancements in tissue engineering may provide supplemental or altern= ative strategies to restore hearing by introducing living, functional cells= to rebuild the auditory pathway. So-called "regenerative strategies" are a= n area of active investigation. This talk will provide a broad review of cu= rrent auditory neuroprosthetics, explore potential future regenerative stra= tegies in hearing restoration, and highlight how fundamental tissue enginee= ring research at the Corporal Michael J. Crescenz VA Medical Center is bein= g applied within this emerging field. The seminar will be hosted on Zoom. You can access the seminars here: https= ://pennmedicine.zoom.us/j/95396120820. This link is also posted on our webs= ite https://sites.google.com/view/ears2020/home<https://urldefense.com/v3/_= _https:/sites.google.com/view/ears2020/home__;!!IBzWLUs!VuGYw2vNd9FQhNjdREs= xtlL_E14Tf-se4AUDBQVfyumou78YqCXbcThOzYXJxUxC6EHsJzXOBQB2L6ef9RRcRtEfe9ER5V= 0DPPDG$>. The E.A.R.S. subscriber list is the ears-seminar google group, wh= ich you can join by emailing: ears2022+subscribe@xxxxxxxx<mailto:ea= rs2022%2Bsubscribe@xxxxxxxx> or visiting the following link: https:= //groups.google.com/g/ears2022<https://urldefense.com/v3/__https:/groups.go= ogle.com/g/ears2022__;!!IBzWLUs!VuGYw2vNd9FQhNjdREsxtlL_E14Tf-se4AUDBQVfyum= ou78YqCXbcThOzYXJxUxC6EHsJzXOBQB2L6ef9RRcRtEfe9ER5V3u372u$>. This will be the last seminar before summer break =96 hope to see you there= ! With kind wishes, Maria Geffen Yale Cohen Steve Eliades Stephen David Alexandria Lesicko Nathan Vogler Jean-Hugues Lestang Huaizhen Cai --_000_MN2PR04MB6127CBA576F2650C4D0C6F11C8719MN2PR04MB6127namp_ Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable <html xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:w=3D"urn:sc= hemas-microsoft-com:office:word" xmlns:m=3D"http://schemas.microsoft.com/of= fice/2004/12/omml" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3D"Content-Type" content=3D"text/html; charset=3DWindows-1= 252"> <meta name=3D"Generator" content=3D"Microsoft Word 15 (filtered medium)"> <style></style> </head> <body lang=3D"EN-US" link=3D"#0563C1" vlink=3D"#954F72" style=3D"word-wrap:= break-word"> <div class=3D"WordSection1"> Dear fellow neuroscientists,<o:p></o:p> <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">  <o:p></o:p></p= > <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px"> Please join us Tomorrow, May 9 at 1:00 pm EDT (UTC-4) for the next edition of = E.A.R.S. (Electronic Auditory Research Seminars), a monthly auditory semina= r series focused on central auditory processing and circuits. <= span style=3D"color:#1D1D1D"><o:p></o:p> <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">  <o:p></o:p></p= > <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px"> Speakers:<o:p></o:p>= <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">  <o:p></o:p></s= pan> <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px"> Charles Anderson (West Virginia Un= iversity): "Cell-type specific enhancement of deviance detecti= on by synaptic zinc in mouse auditory cortex=94 <o:p></o:p> <p class=3D"MsoNormal" style=3D"text-indent:.5in;caret-color: rgb(29, 29, 2= 9);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-w= ebkit-text-size-adjust: auto;-webkit-text-stroke-width: 0px;word-spacing:0p= x"> A fundamental feature of sensory processing is the ability of an= imals to adapt to the current conditions in their the environment yet maint= ain their ability to detect novelty in the same environment. A correlate of this ability is a robust neuronal phenomenon c= alled stimulus-specific adaptation, in which a repeated stimulus will resul= t in smaller and smaller neuronal responses over time, but a deviant stimul= us will still elicit robust responses from the same neurons. Recent work has established that synaptically relea= sed zinc is an endogenous mechanism that shapes neuronal responses to sound= s in the auditory cortex. Here, to understand the contributions of cortical= synaptic zinc to deviance detection of specific cortical neurons we performed wide field and 2-photon calcium = imaging of multiple classes of cortical glutamatergic neurons. We find that= intratelencephalic (IT) neurons in both layer 2/3 and layer 5 as well as e= xtratelencephalic (ET) neurons in layer 5 all demonstrate deviance detection, however, we find a specific en= hancement of this deviance detection in ET neurons that arises from ZnT3-de= pendent synaptic zinc in layer 2/3 IT neurons. Genetic deletion of ZnT3 fro= m layer 2/3 IT neurons removes the enhancing effects of synaptic zinc on ET neuron deviance detection and als= o results in poorer acuity of detecting deviant sounds by behaving mice.</s= pan><o:p></o:p> <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">  <o:p></o:p></s= pan> <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px"> Dayo Adewole (University of Pennsy= lvania): "Tissue Engineering for Auditory Rehabilitation"=  <o:p></o:p> <p class=3D"MsoNormal" style=3D"text-indent:.5in;caret-color: rgb(29, 29, 2= 9);font-variant-caps: normal;orphans: auto;text-align:start;widows: auto;-w= ebkit-text-size-adjust: auto;-webkit-text-stroke-width: 0px;word-spacing:0p= x"> Sensorineural hearing loss (SHL) affects an estimated 18% of the= human population, with the World Health Organization projecting one in ten= people with =91disabling=92 hearing loss by 2050. SHL occurs when cells within the auditory pathway degenerate or die (as a = result of injury, disease, or aging) and is historically considered irrever= sible. Current clinical interventions to restore a degree of hearing follow= ing SHL use implantable devices that deliver electrical impulses to activate the user=92s surviving audito= ry pathway (e.g.cochlear implants); ongoing challenges for these "audi= tory neuroprosthetics" include recreating complex sounds due to limite= d tonotopic resolution & maintaining performance over time as the auditory pathway degenerates. Advancements in tissue engi= neering may provide supplemental or alternative strategies to restore heari= ng by introducing living, functional cells to rebuild the auditory pathway.= So-called "regenerative strategies" are an area of active investigation. This talk will provide a broad review= of current auditory neuroprosthetics, explore potential future regenerativ= e strategies in hearing restoration, and highlight how fundamental tissue e= ngineering research at the Corporal Michael J. Crescenz VA Medical Center is being applied within this emergin= g field.<o:p></o:p> <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">  <o:p></o:p></p= > <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px"> The seminar will be hosted on Zoom. You can access the seminars here: <a href=3D"https://pennmedicine.zo= om.us/j/95396120820" target=3D"_blank" title=3D"https://pennmedicine.zoom.u= s/j/95396120820">https://pennmedicine.zoom.us/j/95396120820</a>. This link is also posted on our website <a href=3D"https://urldefense= .com/v3/__https:/sites.google.com/view/ears2020/home__;!!IBzWLUs!VuGYw2vNd9= FQhNjdREsxtlL_E14Tf-se4AUDBQVfyumou78YqCXbcThOzYXJxUxC6EHsJzXOBQB2L6ef9RRcR= tEfe9ER5V0DPPDG$" target=3D"_blank" title=3D"https://urldefense.com/v3/__ht= tps:/sites.google.com/view/ears2020/home__;!!IBzWLUs!VuGYw2vNd9FQhNjdREsxtl= L_E14Tf-se4AUDBQVfyumou78YqCXbcThOzYXJxUxC6EHsJzXOBQB2L6ef9RRcRtEfe9ER5V0DP= PDG$">= https://sites.google.com/view/ears2020/home</a>. The E.A.R.S. subscriber list is the ears-seminar google group, which you c= an join by emailing: <a href=3D"mailto:ears2022%2Bsubscribe@xxxxxxxx" target=3D"= _blank" title=3D"mailto:ears2022%2Bsubscribe@xxxxxxxx">ears2022+subscribe@xxxxxxxx</a>&nb= sp;or visiting the following link: <a href=3D"https://urldefense.com/v3/__h= ttps:/groups.google.com/g/ears2022__;!!IBzWLUs!VuGYw2vNd9FQhNjdREsxtlL_E14T= f-se4AUDBQVfyumou78YqCXbcThOzYXJxUxC6EHsJzXOBQB2L6ef9RRcRtEfe9ER5V3u372u$" = target=3D"_blank" title=3D"https://urldefense.com/v3/__https:/groups.google= .com/g/ears2022__;!!IBzWLUs!VuGYw2vNd9FQhNjdREsxtlL_E14Tf-se4AUDBQVfyumou78= YqCXbcThOzYXJxUxC6EHsJzXOBQB2L6ef9RRcRtEfe9ER5V3u372u$">https://groups.google.com= /g/ears2022</a>.<o:p></o:p></sp= an> <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">  <o:p></o:p></p= > <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px"> This will be the last seminar before summer bre= ak =96 hope to see you there! <o:= p></o:p> <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px">  <o:p></o:p> <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px"> With kind wishes,<o:p></o:p= > <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px"> Maria Geffen<o:p></o:p></sp= an> <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px"> Yale Cohen<o:p></o:p></span= > <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px"> Steve Eliades<o:p></o:p></s= pan> <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px"> Stephen David<o:p></o:p></s= pan> <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px"> Alexandria Lesicko<o:p></o:= p> <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px"> Nathan Vogler<o:p></o:p></s= pan> <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px"> Jean-Hugues Lestang<o:p></o= :p> <p class=3D"MsoNormal" style=3D"caret-color: rgb(29, 29, 29);font-variant-c= aps: normal;orphans: auto;text-align:start;widows: auto;-webkit-text-size-a= djust: auto;-webkit-text-stroke-width: 0px;word-spacing:0px"> Huaizhen Cai<o:p></o:p></sp= an> <o:p> </o:p> </div> </body> </html> --_000_MN2PR04MB6127CBA576F2650C4D0C6F11C8719MN2PR04MB6127namp_--

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Electrical Engineering Dept., Columbia University