[AUDITORY] Nottingham Hearing Sciences Seminar - Dr Zheng-Yi Chen - 24th March at 1 pm (UK) (Joseph Sollini )

Subject: [AUDITORY] Nottingham Hearing Sciences Seminar - Dr Zheng-Yi Chen - 24th March at 1 pm (UK) From: Joseph Sollini <Joseph.Sollini@xxxxxxxx> Date: Wed, 23 Mar 2022 14:52:14 +0000 --_000_AM9PR06MB8148159FD193AE621B5813E6C5189AM9PR06MB8148eurp_ Content-Type: text/plain; charset="us-ascii" Content-Transfer-Encoding: quoted-printable Hi everyone, Just a reminder that Dr Zheng-Yi Chen will be joining us this Thursday 24th= March at 1.00 pm. Please see details below: Dr Zheng-Yi Chen, Associate Professor, Eaton-Peabody Laboratory, Massachuse= tts Eye & Ear Infirmary, Harvard Medical School Thursday 24th March at 1.00 pm (UK time): "Development of genome editing to treat genetic hearing loss" Abstract: One in 500 newborns suffer from genetic hearing loss for which cochlear imp= lant is the only treatment option. Recent advance in genome editing CRISPR = technology has offered the opportunity to develop new treatment options by = gene editing to correct mutations and to restore hearing in patients. We ha= ve been developing genome editing as treatment for genetic hearing loss in = two ways. First, we have shown that by a liposomal mediated ribonucleoprote= ins (RNP) approach that CRISPR/gRNA complex can be effectively delivered in= to the mouse inner ear for DNA editing in the hair cells. Second, we used t= he liposomal-RNP delivery to target genetic mutations in two mouse models o= f human genetic hearing loss, one with a mutation in the Tmc1 gene in the i= nner hair cells and one with a mutation in the Atp2b2 in the outer hair cel= ls. We showed that precise genome editing in each model resulted in rescue = of hearing over time. Our approach elicited minimum off-target effect, a sa= fety concern for the editing-based therapy. We further demonstrate that th= e editing approach can target two mutations from different genes by a singl= e injection with hearing rescue. Our work laid the foundation for the devel= opment of new treatments for genetic hearing loss in patients. Biography: Dr. Zheng-Yi Chen, is an associate professor of the Department of Otolaryng= ology-Head and Neck Surgery, Harvard Medical School and Massachusetts Eye &= ear Infirmary. He obtained BSc from Sichuan University in China and his DP= hil in human genetics from Oxford University, UK. He did his postdoctoral f= ellowship at the Massachusetts General Hospital/Harvard Medical School. His laboratory is focused on the development of new treatments for diverse = forms of hearing loss including genetic hearing loss, age-related and envir= onmental-related hearing loss. Their approaches include AAV gene therapy, g= enome editing and inner ear hair cell regeneration. His laboratory has been= involved in identification of numerous genetic deafness genes, editing to = treat mouse models of human genetic hearing loss, regeneration of hair cell= s in mature mammalian inner ear. Other work includes the creation of pig mo= dels for human genetic hearing loss and the development of novel nanopartic= le vehicles inner ear delivery. Details should already be in your calendar, but here is the link in case yo= u want to forward it to colleagues. Microsoft Teams meeting - Dr Zheng-Yi Chen Join on your computer or mobile app Click here to join the meeting<https://teams.microsoft.com/l/meetup-join/19= %3ameeting_YzEyMzg2OTItY2RiZC00YjdlLWIzOGItMDA5NmU2MTA0ZjJm%40thread.v2/0?c= ontext=3D%7b%22Tid%22%3a%2267bda7ee-fd80-41ef-ac91-358418290a1e%22%2c%22Oid= %22%3a%22a04db259-744c-438c-a55a-fcb9a68bc359%22%7d> We look forward to seeing you there. Best wishes, Joe 1.00 pm / 13:00 (GMT/Greenwich Mean Time) 2.00 pm / 14:00 (CET/Central European Time) 6.00 am / 06:00 (USA Pacific) 8.00 am / 08:00 (USA Central) 9.00 am / 09:00 (USA Eastern) 09.00 pm / 21:00 (CST/China Standard Time) Dr Joseph Sollini Auditory Circuits Lab Hearing Sciences Mental Health and Clinical Neuroscience, School of Medicine The University of Nottingham W: https://www.nottingham.ac.uk/research/groups/hearingsciences/people/jose= ph.sollini W: https://orcid.org/0000-0002-1974-4291 This message and any attachment are intended solely for the addressee and may contain confidential information. If you have received this message in error, please contact the sender and delete the email and attachment.=20 Any views or opinions expressed by the author of this email do not necessarily reflect the views of the University of Nottingham. Email communications with the University of Nottingham may be monitored=20 where permitted by law. --_000_AM9PR06MB8148159FD193AE621B5813E6C5189AM9PR06MB8148eurp_ Content-Type: text/html; charset="us-ascii" Content-Transfer-Encoding: quoted-printable <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-micr= osoft-com:office:office" xmlns:w=3D"urn:schemas-microsoft-com:office:word" = xmlns:m=3D"http://schemas.microsoft.com/office/2004/12/omml" xmlns=3D"http:= //www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3D"Content-Type" content=3D"text/html; charset=3Dus-ascii"> <meta name=3D"Generator" content=3D"Microsoft Word 15 (filtered medium)"> <style></style> </head> <body lang=3D"EN-GB" link=3D"#0563C1" vlink=3D"#954F72" style=3D"word-wrap:= break-word"> <div class=3D"WordSection1"> Hi everyone,<o:p></o:p> <o:p> </o:p> Just a reminder that Dr Zheng-Yi Chen will be joinin= g us this Thursday 24th March at 1.00 pm. Please see details bel= ow:<o:p></o:p> <o:p> </o:p> Dr Zheng-Yi Chen= , Associate Professor, Eaton-Peabody Laboratory, Massachusetts Eye & Ear Infirmary, Harvard Medical School<o:p></o:p> Thursday 24th</su= p> March at 1.00 pm (UK time):<o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px">  <o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px"> “D= evelopment of genome editing to treat genetic hearing loss”</b= ><o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px">  <o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px"> Abstract: <o:p></= o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px"> One in 500 newborns suffer from genetic hearing loss for which c= ochlear implant is the only treatment option. Recent advance in genome edit= ing CRISPR technology has offered the opportunity to develop new treatment options by gene editing to correct mu= tations and to restore hearing in patients. We have been developing genome = editing as treatment for genetic hearing loss in two ways. First, we have s= hown that by a liposomal mediated ribonucleoproteins (RNP) approach that CRISPR/gRNA complex can be effectiv= ely delivered into the mouse inner ear for DNA editing in the hair cells. S= econd, we used the liposomal-RNP delivery to target genetic mutations in tw= o mouse models of human genetic hearing loss, one with a mutation in the Tmc1 gene in the= inner hair cells and one with a mutation in the Atp2b2 in= the outer hair cells. We showed that precise genome editing in each model = resulted in rescue of hearing over time. Our approach elicited minimum off-target effect, a safety concern for the editing-based= therapy.  We further demonstrate that the editing approach can target= two mutations from different genes by a single injection with hearing resc= ue. Our work laid the foundation for the development of new treatments for genetic hearing loss in patients.</s= pan><o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px">  <o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px"> Biography: <o:p><= /o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px"> Dr. Zheng-Yi Chen, is an associate professor of the Depar= tment of Otolaryngology-Head and Neck Surgery, Harvard Medical School and Massachusetts Eye & ear Infirmary. He obtained BSc = from Sichuan University in China and his DPhil in human genetics from Oxfor= d University, UK. He did his postdoctoral fellowship at the Massachusetts G= eneral Hospital/Harvard Medical School.<o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px"> His laboratory is focused on the development of new treatments for= diverse forms of hearing loss including genetic hearing loss, age-related = and environmental-related hearing loss. Their approaches include AAV gene therapy, genome editing and inner ear ha= ir cell regeneration. His laboratory has been involved in identification of= numerous genetic deafness genes, editing to treat mouse models of human ge= netic hearing loss, regeneration of hair cells in mature mammalian inner ear. Other work includes the creat= ion of pig models for human genetic hearing loss and the development of nov= el nanoparticle vehicles inner ear delivery.<o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px">  <o:p></o:p> Details should already be= in your calendar, but here is the link in case you want to forward it to c= olleagues.<o:p></o:p>  <o:p></o:p> <p style=3D"margin:0cm;background:white;vertical-align:baseline;font-varian= t-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:start;w= idows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;= text-decoration-style: initial;text-decoration-color: initial;word-spacing:= 0px"> Mic= rosoft Teams meeting – Dr Zheng-Yi=  Chen<o:p></o:p> <p style=3D"margin:0cm;line-height:11.65pt;background:white;vertical-align:= baseline;font-variant-ligatures: normal;font-variant-caps: normal;orphans: = 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration= -thickness: initial;text-decoration-style: initial;text-decoration-color: i= nitial;word-spacing:0px"> = Join on your computer or mobile app<o:p></o:p> <p style=3D"margin:0cm;line-height:11.65pt;background:white;vertical-align:= baseline;font-variant-ligatures: normal;font-variant-caps: normal;orphans: = 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration= -thickness: initial;text-decoration-style: initial;text-decoration-color: i= nitial;word-spacing:0px"> <a href=3D"https://t= eams.microsoft.com/l/meetup-join/19%3ameeting_YzEyMzg2OTItY2RiZC00YjdlLWIzO= GItMDA5NmU2MTA0ZjJm%40thread.v2/0?context=3D%7b%22Tid%22%3a%2267bda7ee-fd80= -41ef-ac91-358418290a1e%22%2c%22Oid%22%3a%22a04db259-744c-438c-a55a-fcb9a68= bc359%22%7d" target=3D"_blank">Click here to join the meeting</a><o= :p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px">  <o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px"> We look forward to seeing you there.<o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px">  <o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px"> Best wishes,<o:p></o:p></span= > <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px"> Joe<o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px">  <o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px"> 1.00 pm / 13:00 (= GMT/Greenwich Mean Time)   <o:p></o:p><= /p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px"> 2.00 pm / 14:00 (= CET/Central European Time)   <o:p></o:p></span= > <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px"> 6.00 am / 06:00 (= USA Pacific)<o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px"> 8.00 am / 08:00 (= USA Central)<o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px"> 9.00 am / 09:00 (= USA Eastern)  <o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px"> 09.00 pm / 21:00 = (CST/China Standard Time) <o:p></o:p> <p style=3D"margin:0cm;background:white;font-variant-ligatures: normal;font= -variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-st= roke-width: 0px;text-decoration-thickness: initial;text-decoration-style: i= nitial;text-decoration-color: initial;word-spacing:0px">  <o:p></o:p> <o:p> </o:p> Dr Joseph Sollini<o:p></o:p> Auditory Circuits Lab<o:p></o:p> Hearing Sciences<o:p></o:p> Mental Health and Clinical Neuroscience, School of Medicine<o:p></o:p>= The University of Nottingham<o:p></o:p> <o:p> </o:p> W: <a href=3D"https://www.nottingham.ac.uk/research/groups/hearingscie= nces/people/joseph.sollini"> https://www.nottingham.ac.uk/research/groups/= hearingsciences/people/joseph.sollini</a><o:p></o:p> W: <a href=3D"https://orcid.org/0000-0002-1974-4291"> https://orcid.org/0000-0002-1974-4291<= /a><o:p></o:p> <o:p> </o:p> <o:p> </o:p> </div> <PRE> This message and any attachment are intended solely for the addressee and may contain confidential information. If you have received this message in error, please contact the sender and delete the email and attachment.=20 Any views or opinions expressed by the author of this email do not necessarily reflect the views of the University of Nottingham. Email communications with the University of Nottingham may be monitored=20 where permitted by law. </PRE></body> </html> --_000_AM9PR06MB8148159FD193AE621B5813E6C5189AM9PR06MB8148eurp_--

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