Subject: [AUDITORY] Seminar Announcement - November 30 - E.A.R.S. (Electronic Auditory Research Seminars) From: "Vogler, Nathan" <Nathan.Vogler@xxxxxxxx> Date: Tue, 23 Nov 2021 23:30:45 +0000--_000_MN2PR04MB6127681DE74082EC4867B1F9C8609MN2PR04MB6127namp_ Content-Type: text/plain; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Dear fellow neuroscientists, We would like to invite you to join us on Tuesday, November 30 at 1:00 pm E= ST (UTC-5) for the next edition of E.A.R.S. (Electronic Auditory Research S= eminars), a monthly auditory seminar series with the focus on central audit= ory processing and circuits. Please pre-register (for free) and tune in via= Crowdcast (enter your email to receive the link for the talk): https://www= .crowdcast.io/e/ears/12 (Note: for optimal performance, we recommend using Google Chrome as your br= owser). Dr. Hiroyuki Kato (University of North Carolina at Chapel Hill): "Cortical = area-specific roles in spectro-temporal integration" In our daily life, even in the face of multiple sound source= s, our brain binds together frequency components that belong to the same so= urce and recognizes individual sound objects. This =93feature binding=94 re= lies on the precise synchrony of each component=92s onset timing, but littl= e is known regarding its neural correlates. Here, we find that multi-freque= ncy sounds prevalent in vocalizations, specifically harmonics, preferential= ly activate the mouse secondary auditory cortex (A2), whose response sharpl= y deteriorates with shifts in component onset timings. The temporal window = for harmonics integration in A2 was broadened by inactivation of somatostat= in-expressing interneurons (SOM cells), but not parvalbumin-expressing inte= rneurons (PV cells). Importantly, A2 has functionally connected subnetworks= of neurons preferentially encoding coincident harmonics. These subnetworks= are stable across days and exist prior to experimental harmonics exposure,= suggesting their formation during development. Therefore, we propose A2 as= a locus for multi-frequency integration, which may form the circuit basis = for vocal processing. In this seminar, I will further discuss the dispariti= es between the location of functionally identified A2 and the representatio= n of =93AuV=94 in brain atlases. Our data show that stereotaxic targeting o= f auditory cortical areas is prone to inaccuracy due to the marked spatial = variability across individuals. These results call for the reconsideration = of the usage of brain atlases and suggest the necessity of functional mappi= ng in dissecting the hierarchically organized auditory cortices. Dr. Mitchell Sutter (University of California, Davis): "Task Dependence of = Attentional Modulation of Auditory Cortical Coding" Attention improves our ability to process sounds in complex= hearing environments. We are investigating how attention works to improve= the neuronal encoding of sound. In this talk we describe how different fo= rms of attention and different types of stimulus discriminations can dramat= ically change how the auditory cortex encodes sounds and how attention mani= fests itself in single neuron signals. We will specifically compare three = tasks: simple amplitude modulation (AM) detection, selective feature attent= ion where you must attend to either the modulation or the carrier of AM, an= d intermodal attention where you must attend to either an auditory or visua= l stimulus which are presented simultaneously. The results show that the fo= rm of neural code (opponent versus non-opponent code) as well as whether at= tention is manifested at the single neuron level or the population level is= heavily dependent on how ambiguous a single neuron rate code is at encodin= g the AM. The results also show a higher level of complexity in primary au= ditory cortex than one would expect including encoding of behavioral contex= t, independent of the sound processing properties of the neuron Additional upcoming E.A.R.S. seminars: December 14, at 1:00 pm ET =96 Trainee talks With kind wishes, Maria Geffen Yale Cohen Steve Eliades Stephen David Alexandria Lesicko Nathan Vogler Jean-Hugues Lestang Huaizhen Cai --_000_MN2PR04MB6127681DE74082EC4867B1F9C8609MN2PR04MB6127namp_ Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable <html xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:w=3D"urn:sc= hemas-microsoft-com:office:word" xmlns:m=3D"http://schemas.microsoft.com/of= fice/2004/12/omml" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3D"Content-Type" content=3D"text/html; charset=3DWindows-1= 252"> <meta name=3D"Generator" content=3D"Microsoft Word 15 (filtered medium)"> <style><!-- /* Font Definitions */ @xxxxxxxx {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4;} @xxxxxxxx {font-family:Calibri; panose-1:2 15 5 2 2 2 4 3 2 4;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {margin:0in; font-size:11.0pt; font-family:"Calibri",sans-serif;} span.EmailStyle17 {mso-style-type:personal-compose; font-family:"Calibri",sans-serif; color:windowtext;} span.apple-converted-space {mso-style-name:apple-converted-space;} .MsoChpDefault {mso-style-type:export-only; font-family:"Calibri",sans-serif;} @xxxxxxxx WordSection1 {size:8.5in 11.0in; margin:1.0in 1.0in 1.0in 1.0in;} div.WordSection1 {page:WordSection1;} --></style> </head> <body lang=3D"EN-US" link=3D"#0563C1" vlink=3D"#954F72" style=3D"word-wrap:= break-word"> <div class=3D"WordSection1"> <p style=3D"margin:0in"><span style=3D"font-size:11.0pt;color:black;border:= none windowtext 1.0pt;padding:0in">Dear fellow neuroscientists,</span><span= style=3D"font-size:11.0pt;font-family:"Calibri",sans-serif;color= :black"> </span><span style=3D"font-size:13.5pt;color:black"><o:p></o:= p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in"> </span><span style=3D"font-size:11.0pt;font-family:"C= alibri",sans-serif;color:black"> </span><span style=3D"font-size:= 13.5pt;color:black"><o:p></o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in">We would like to invite you to join us on <b>Tuesday, Novem= ber 30 at 1:00 pm EST</b> (UTC-5) for the next edition of E.A.R.S. (El= ectronic Auditory Research Seminars), a monthly auditory seminar series with the focus on central auditory processing and = circuits. Please pre-register (for free) and tune in via Crowdcast (enter y= our email to receive the link for the talk):</span><span class=3D"apple-con= verted-space"><span style=3D"color:black;border:none windowtext 1.0pt;paddi= ng:0in"> </span></span><span style=3D"font-size:11.0pt;color:black;bor= der:none windowtext 1.0pt;padding:0in">https://www.crowdcast.io/e/ears/12</= span><span style=3D"font-size:13.5pt;color:black"><o:p></o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(255, 255, 255);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in">(Note: for optimal performance, we recommend using Google Chrome= as your browser).</span><span style=3D"font-size:11.0pt;font-family:"= Calibri",sans-serif;color:black"> </span><span style=3D"font-size= :13.5pt;color:black"><o:p></o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in"> </span><span style=3D"font-size:11.0pt;font-family:"C= alibri",sans-serif;color:black"> </span><span style=3D"font-size:= 13.5pt;color:black"><o:p></o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <b><span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt= ;padding:0in">Dr. Hiroyuki Kato </span></b><span style=3D"font-si= ze:11.0pt;color:black;border:none windowtext 1.0pt;padding:0in">(University= of North Carolina at Chapel Hill): <i>"Cortical area-specific roles in spectro-temporal integration"</i><o:p></o:p></= span></p> <p style=3D"margin:0in"><span style=3D"font-size:11.0pt;color:black;border:= none windowtext 1.0pt;padding:0in">  = ; In our daily life, even in the face of multiple sound source= s, our brain binds together frequency components that belong to the same so= urce and recognizes individual sound objects. This =93feature binding=94 relies= on the precise synchrony of each component=92s onset timing, but little is= known regarding its neural correlates. Here, we find that multi-frequency = sounds prevalent in vocalizations, specifically harmonics, preferentially activate the mouse secondary auditory cortex (A2= ), whose response sharply deteriorates with shifts in component onset timin= gs. The temporal window for harmonics integration in A2 was broadened by in= activation of somatostatin-expressing interneurons (SOM cells), but not parvalbumin-expressing interneurons (PV = cells). Importantly, A2 has functionally connected subnetworks of neurons p= referentially encoding coincident harmonics. These subnetworks are stable a= cross days and exist prior to experimental harmonics exposure, suggesting their formation during development. Therefo= re, we propose A2 as a locus for multi-frequency integration, which may for= m the circuit basis for vocal processing. In this seminar, I will further d= iscuss the disparities between the location of functionally identified A2 and the representation of =93AuV=94= in brain atlases. Our data show that stereotaxic targeting of auditory cor= tical areas is prone to inaccuracy due to the marked spatial variability ac= ross individuals. These results call for the reconsideration of the usage of brain atlases and suggest the nece= ssity of functional mapping in dissecting the hierarchically organized audi= tory cortices.<o:p></o:p></span></p> <p style=3D"margin:0in"><span style=3D"font-size:13.5pt;color:black"> = <o:p></o:p></span></p> <p style=3D"margin:0in"><b><span style=3D"font-size:11.0pt;color:black;bord= er:none windowtext 1.0pt;padding:0in">Dr. Mitchell Sutter </span>= </b><span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0p= t;padding:0in">(University of California, Davis): <i>"Task Dependence of Attentional Modulation of Auditory Cortical Coding"</i>= <o:p></o:p></span></p> <p style=3D"margin:0in"><span style=3D"font-size:11.0pt;color:black;border:= none windowtext 1.0pt;padding:0in">  = ; Attention improves our ability to process sounds in co= mplex hearing environments. We are investigating how attention works = to improve the neuronal encoding of sound. In this talk we describe how differe= nt forms of attention and different types of stimulus discriminations can d= ramatically change how the auditory cortex encodes sounds and how attention= manifests itself in single neuron signals. We will specifically compare three tasks: simple amplitude modulatio= n (AM) detection, selective feature attention where you must attend to eith= er the modulation or the carrier of AM, and intermodal attention where you = must attend to either an auditory or visual stimulus which are presented simultaneously. The results show that = the form of neural code (opponent versus non-opponent code) as well as whet= her attention is manifested at the single neuron level or the population le= vel is heavily dependent on how ambiguous a single neuron rate code is at encoding the AM. The resul= ts also show a higher level of complexity in primary auditory cortex than o= ne would expect including encoding of behavioral context, independent of th= e sound processing properties of the neuron<o:p></o:p></span></p> <p style=3D"margin:0in"><span style=3D"font-size:11.0pt;color:black;border:= none windowtext 1.0pt;padding:0in;background:white"> </span><span styl= e=3D"font-size:11.0pt;font-family:"Calibri",sans-serif;color:blac= k"> </span><span style=3D"font-size:13.5pt;color:black"><o:p></o:p></s= pan></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in;background:white">Additional upcoming E.A.R.S. seminars:</span><s= pan style=3D"font-size:11.0pt;font-family:"Calibri",sans-serif;co= lor:black"> </span><span style=3D"font-size:13.5pt;color:black"><o:p><= /o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <b><span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt= ;padding:0in;background:white">December 14</span></b><span style=3D"font-si= ze:11.0pt;color:black;border:none windowtext 1.0pt;padding:0in;background:w= hite">, at 1:00 pm ET</span><span style=3D"font-size:11.0pt;font-family:&qu= ot;Calibri",sans-serif;color:black"> =96 <b>Trainee talks</b></span><span style=3D"font-size:13.5pt;color:black"><o:= p></o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in"> </span><span style=3D"font-size:11.0pt;font-family:"C= alibri",sans-serif;color:black"> </span><span style=3D"font-size:= 13.5pt;color:black"><o:p></o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in">With kind wishes,</span><span style=3D"font-size:11.0pt;font-fam= ily:"Calibri",sans-serif;color:black"> </span><span style=3D= "font-size:13.5pt;color:black"><o:p></o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in"> </span><span style=3D"font-size:11.0pt;font-family:"C= alibri",sans-serif;color:black"> </span><span style=3D"font-size:= 13.5pt;color:black"><o:p></o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in">Maria Geffen</span><span style=3D"font-size:11.0pt;font-family:&= quot;Calibri",sans-serif;color:black"> </span><span style=3D"font= -size:13.5pt;color:black"><o:p></o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in">Yale Cohen</span><span style=3D"font-size:11.0pt;font-family:&qu= ot;Calibri",sans-serif;color:black"> </span><span style=3D"font-s= ize:13.5pt;color:black"><o:p></o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in">Steve Eliades</span><span style=3D"font-size:11.0pt;font-family:= "Calibri",sans-serif;color:black"> </span><span style=3D"fon= t-size:13.5pt;color:black"><o:p></o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in">Stephen David</span><span style=3D"font-size:11.0pt;font-family:= "Calibri",sans-serif;color:black"> </span><span style=3D"fon= t-size:13.5pt;color:black"><o:p></o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in">Alexandria Lesicko</span><span style=3D"font-size:11.0pt;font-fa= mily:"Calibri",sans-serif;color:black"> </span><span style= =3D"font-size:13.5pt;color:black"><o:p></o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in">Nathan Vogler</span><span style=3D"font-size:11.0pt;font-family:= "Calibri",sans-serif;color:black"> </span><span style=3D"fon= t-size:13.5pt;color:black"><o:p></o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in">Jean-Hugues Lestang</span><span style=3D"font-size:11.0pt;font-f= amily:"Calibri",sans-serif;color:black"> </span><span style= =3D"font-size:13.5pt;color:black"><o:p></o:p></span></p> <p style=3D"margin:0in;font-variant-caps: normal;orphans: auto;text-align:s= tart;widows: auto;-webkit-text-size-adjust: auto;-webkit-text-stroke-width:= 0px;caret-color: rgb(225, 224, 223);word-spacing:0px"> <span style=3D"font-size:11.0pt;color:black;border:none windowtext 1.0pt;pa= dding:0in">Huaizhen Cai</span><span style=3D"font-size:11.0pt;font-family:&= quot;Calibri",sans-serif;color:black"> </span><span style=3D"font= -size:13.5pt;color:black"><o:p></o:p></span></p> <p class=3D"MsoNormal"><o:p> </o:p></p> </div> </body> </html> --_000_MN2PR04MB6127681DE74082EC4867B1F9C8609MN2PR04MB6127namp_--