Subject: [AUDITORY] Summary - Cortical sources of auditory steady state response From: "Patel, Aniruddh D." <a.patel@xxxxxxxx> Date: Fri, 31 Jan 2020 13:51:18 +0000 List-Archive:<http://lists.mcgill.ca/scripts/wa.exe?LIST=AUDITORY>--_000_E06FF38A806E884E9F935E87BFE5694C01425C222Etabvmexdag1mb_ Content-Type: text/plain; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Dear List, Thank you to those who replied to my query. A summary of responses is bel= ow. Apologies if I left anyone out by accident. Ani Patel Original query on Jan 19, 2020 Dear List, Can anyone point me to recent work on cortical sources of the ~40 Hz audito= ry steady state response? Some older papers argue that the sources are in auditory cortex, while othe= rs argue that there are multiple sources in different parts of the cortex, = e.g.,: https://link.springer.com/article/10.1023/A:1021470822922 https://www.sciencedirect.com/science/article/pii/S0378595504004009 I'm curious what the latest research suggests. Responses: In my PhD I worked on the brain sources of ASSRs. Maybe the following paper= s can be helpful for you. https://www.sciencedirect.com/science/article/pii/S1053811919301338 https://www.biorxiv.org/content/biorxiv/early/2019/12/03/859405.full.pdf https://www.sciencedirect.com/science/article/pii/S1053811917300381 In short, I found that in addition to the primary sources in auditory corte= x, some sources beyond auditory cortex (for example in motor area) are also= responding to AM stimuli. - Ehsan D. Farahani --- I've recently been doing some work on ASSR, including 40 Hz responses, so I= think I might be able to point you towards some related studies. I must ad= mit however I have not worked directly with localisation of ASSR sources wi= th EEG or otherwise. I think a great resource for you would be the work of Bernhard Ross: https:= //www.researchgate.net/profile/Bernhard_Ross You can see back in 2005 and 2= 006 he has three papers dealing directly with the 40Hz ASSR. You might be a= ble to find more recent papers though some of his co-authors who may be sti= ll working on ASSR. You might also consider possible works related to the relatively recent pap= er: https://www.ncbi.nlm.nih.gov/pubmed/29092566. I realise this if for a h= igher frequency range than your request, but it seems logical to me that 40= Hz responses would also be a superposition from various frequency tuned ar= eas, in addition to perhaps higher order cortical processing. I myself am much more in favour of a multi-source model, both in low and hi= gh frequency ranges. My own work recently has shown that 40 Hz responses ca= n be greatly suppressed and redistributed when stimulated binaurally, but i= n interaural antiphase. Of course this doesn't affect the subject ability t= o hear the stimulus, but the superposition of the combined responses of the= neural generators is suppressive. - Sam Watson --- We've looked at this a bit in relation to FFR (similar in flavor but more t= han just the envelope locking response). https://www.memphis.edu/acnl/publications/pdfs/neuroimage2018.pdf The references therein also cover known sources of ASSR. The Kuwada article= is also a seminal paper to look at. Of course if you're at 40 Hz, you also= have to think about brainstem contributions. Kuwada, S., Anderson, J. S., Batra, R., Fitzpatrick, D. C., Teissier, N., &= D'Angelo, W. R. (2002). Sources of the scalp-recorded amplitude-modulation= following response. Journal of the American Academy of Audiology, 13(4), 1= 88-204. - Gavin Bidelman --- Not specifically 40 Hz, but plenty of evidence for greater frequency follow= ing at primary compared to non-primary auditory cortical sites for rates ei= ther side of 40 Hz, e.g. in Fig. 1 in https://www.jneurosci.org/content/39/= 44/8679 or Fig 2. in https://pubmed.ncbi.nlm.nih.gov/19675285-coding-of-re= petitive-transients-by-auditory-cortex-on-heschls-gyrus/ - Alex Billig --- This work of Luc Arnal is promising and relevant I think, although not exac= tly addressing your issue. https://www.nature.com/articles/s41467-019-11626-7 and also this work from my group (very much neurophysiology based approach) https://www.biorxiv.org/content/10.1101/834226v1 - Danielle Schon --- We wrote a paper a few years back looking at the location of 40 Hz ASSRs in= Neuroimage. Luke, R., De Vos, A., & Wouters, J. (2017). Source analysis of auditory ste= ady-state responses in acoustic and electric hearing. NeuroImage, 147, 568-= 576. I spent quite some time looking at different methods of analysis, for the 4= 0 Hz ASSR the results were very consistent as described in the article rega= rdless of analysis approach (likely due to the high SNR at this modulation = rate). There is also some additional work from the last author (Prof Jan Wouters) = that may be of interest to you. - Robert Luke --- A few years ago we published a paper on 40-Hz ASSR in sedated and anaesthet= ised infants children (M=FChler et al., 2014). On the basis of our recordi= ngs we concluded that there is a robust brainstem component also for 40 Hz = ASSR. Reference R M=FChler, T Rahne, K Mentzel, J L Verhey "40-Hz multiple auditory steady-= state responses to narrow-band chirps in sedated and anaesthetized infants"= , International Journal of Pediatric Otorhinolaryngology 78 (2014) 762-768 - Jesko Verhey --- We have one recent paper - not accepted yet - with B. Morillon and D. Sch= =F6n on the topic. With sEEG + MEG, we have shown cortical sources for ~ 60= /80 Hz oscillatory responses distributed throughout the cortex : auditory c= ortex but also up to inferior frontal and motor cortical regions (see Figur= e 1). https://www.biorxiv.org/content/10.1101/834226v1 - Jacques Pesnot Lerousseau. ---- Our two recent papers may be relevant to your question, though not specifi= cally on this issue. The data suggested that the sources are in auditory co= rtex. Concurrent temporal channels for auditory processing: Oscillatory neural en= trainment reveals segregation of function at different scales https://journals.plos.org/plosbiology/article?id=3D10.1371%2Fjournal.pbio.2= 000812 Theta and Gamma Bands Encode Acoustic Dynamics over Wide-Ranging Timescales https://academic.oup.com/cercor/advance-article-abstract/doi/10.1093/cercor= /bhz263/5637582 - Xiangbin End of responses --_000_E06FF38A806E884E9F935E87BFE5694C01425C222Etabvmexdag1mb_ Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-micr= osoft-com:office:office" xmlns:w=3D"urn:schemas-microsoft-com:office:word" = xmlns:m=3D"http://schemas.microsoft.com/office/2004/12/omml" xmlns=3D"http:= //www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3D"Content-Type" content=3D"text/html; charset=3Diso-8859-= 1"> <meta name=3D"Generator" content=3D"Microsoft Word 15 (filtered medium)"> <style><!-- /* Font Definitions */ @xxxxxxxx {font-family:Wingdings; 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mso-level-text:o; mso-level-tab-stop:none; mso-level-number-position:left; text-indent:-.25in; font-family:"Courier New";} @xxxxxxxx l2:level9 {mso-level-number-format:bullet; mso-level-text:\F0A7; mso-level-tab-stop:none; mso-level-number-position:left; text-indent:-.25in; font-family:Wingdings;} ol {margin-bottom:0in;} ul {margin-bottom:0in;} --></style><!--[if gte mso 9]><xml> <o:shapedefaults v:ext=3D"edit" spidmax=3D"1026" /> </xml><![endif]--><!--[if gte mso 9]><xml> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1" /> </o:shapelayout></xml><![endif]--> </head> <body lang=3D"EN-US" link=3D"#0563C1" vlink=3D"#954F72"> <div class=3D"WordSection1"> <p class=3D"MsoNormal">Dear List,<o:p></o:p></p> <p class=3D"MsoNormal">Thank you to those who replied to my query. &nb= sp; A summary of responses is below. Apologies if I left anyone out by acci= dent.<o:p></o:p></p> <p class=3D"MsoNormal">Ani Patel<o:p></o:p></p> <p class=3D"MsoNormal"><o:p> </o:p></p> <p class=3D"MsoNormal"><b>Original query on Jan 19, 2020<o:p></o:p></b></p> <p class=3D"MsoNormal">Dear List,<o:p></o:p></p> <p class=3D"MsoNormal">Can anyone point me to recent work on cortical sourc= es of the ~40 Hz auditory steady state response?<o:p></o:p></p> <p class=3D"MsoNormal">Some older papers argue that the sources are in audi= tory cortex, while others argue that there are multiple sources in differen= t parts of the cortex, e.g.,:<o:p></o:p></p> <p class=3D"MsoNormal"><span class=3D"MsoHyperlink"><a href=3D"https://link= .springer.com/article/10.1023/A:1021470822922">https://link.springer.com/ar= ticle/10.1023/A:1021470822922</a></span><span style=3D"color:#1F497D"><o:p>= </o:p></span></p> <p class=3D"MsoNormal"><span class=3D"MsoHyperlink"><a href=3D"https://www.= sciencedirect.com/science/article/pii/S0378595504004009">https://www.scienc= edirect.com/science/article/pii/S0378595504004009</a></span><span style=3D"= color:#1F497D"><o:p></o:p></span></p> <p class=3D"MsoNormal">I’m curious what the latest research suggests.= <o:p></o:p></p> <p class=3D"MsoNormal"><br> <b>Responses:<o:p></o:p></b></p> <p class=3D"MsoNormal"><o:p> </o:p></p> <p class=3D"MsoNormal">In my PhD I worked on the brain sources of ASSRs. Ma= ybe the following papers can be helpful for you.<o:p></o:p></p> <p class=3D"MsoNormal"><span class=3D"MsoHyperlink"><a href=3D"https://www.= sciencedirect.com/science/article/pii/S1053811919301338">https://www.scienc= edirect.com/science/article/pii/S1053811919301338</a></span><o:p></o:p></p> <p class=3D"MsoNormal"><span class=3D"MsoHyperlink"><a href=3D"https://www.= biorxiv.org/content/biorxiv/early/2019/12/03/859405.full.pdf">https://www.b= iorxiv.org/content/biorxiv/early/2019/12/03/859405.full.pdf</a></span><o:p>= </o:p></p> <p class=3D"MsoNormal"><span class=3D"MsoHyperlink"><a href=3D"https://www.= sciencedirect.com/science/article/pii/S1053811917300381">https://www.scienc= edirect.com/science/article/pii/S1053811917300381</a></span> <o:p></o:p></p> <p class=3D"MsoNormal">In short, I found that in addition to the primary so= urces in auditory cortex, some sources beyond auditory cortex (for example = in motor area) are also responding to AM stimuli. <o:p></o:p></p> <p class=3D"MsoListParagraph" style=3D"text-indent:-.25in;mso-list:l2 level= 1 lfo1"><![if !supportLists]><span style=3D"mso-list:Ignore">-<span style= =3D"font:7.0pt "Times New Roman""> &= nbsp; </span></span><![endif]>Ehsan D. Farahani<o:p></o:p></p> <p class=3D"MsoNormal">---<o:p></o:p></p> <p class=3D"MsoNormal"><span lang=3D"EN-GB">I’ve recently been doing = some work on ASSR, including 40 Hz responses, so I think I might be able to= point you towards some related studies. I must admit however I have not wo= rked directly with localisation of ASSR sources with EEG or otherwise.<o:p></o:p></span></p> <p class=3D"MsoNormal"><span lang=3D"EN-GB">I think a great resource for yo= u would be the work of Bernhard Ross: <span class=3D"MsoHyperlink"><a href=3D"https://www.researchgate.net/profil= e/Bernhard_Ross">https://www.researchgate.net/profile/Bernhard_Ross</a></sp= an> You can see back in 2005 and 2006 he has three papers dealing directly = with the 40Hz ASSR. You might be able to find more recent papers though some of his co-authors who may be still = working on ASSR.<o:p></o:p></span></p> <p class=3D"MsoNormal"><span lang=3D"EN-GB">You might also consider possibl= e works related to the relatively recent paper: <span class=3D"MsoHyperlink"><a href=3D"https://www.ncbi.nlm.nih.gov/pubmed= /29092566">https://www.ncbi.nlm.nih.gov/pubmed/29092566</a></span>. I reali= se this if for a higher frequency range than your request, but it seems log= ical to me that 40 Hz responses would also be a superposition from various frequency tuned areas, in addition to= perhaps higher order cortical processing.<o:p></o:p></span></p> <p class=3D"MsoNormal"><span lang=3D"EN-GB">I myself am much more in favour= of a multi-source model, both in low and high frequency ranges. My own wor= k recently has shown that 40 Hz responses can be greatly suppressed and red= istributed when stimulated binaurally, but in interaural antiphase. Of course this doesn’t affect the subje= ct ability to hear the stimulus, but the superposition of the combined resp= onses of the neural generators is suppressive.<o:p></o:p></span></p> <p class=3D"MsoListParagraph" style=3D"text-indent:-.25in;mso-list:l2 level= 1 lfo1"><![if !supportLists]><span lang=3D"DA" style=3D"mso-fareast-languag= e:DA"><span style=3D"mso-list:Ignore">-<span style=3D"font:7.0pt "Time= s New Roman""> </span></span></span><![endif]><span style=3D"mso-fareast-language:DA">Sam = Watson </span> <span lang=3D"DA" style=3D"mso-fareast-language:DA"><o:p></o:p></span></p> <p class=3D"MsoNormal"><span lang=3D"EN-GB"><o:p> </o:p></span></p> <p class=3D"MsoNormal">---<o:p></o:p></p> <p class=3D"MsoNormal">We've looked at this a bit in relation to FFR (simil= ar in flavor but more than just the envelope locking response). <o:p><= /o:p></p> <p class=3D"MsoNormal"><span class=3D"MsoHyperlink"><a href=3D"https://www.= memphis.edu/acnl/publications/pdfs/neuroimage2018.pdf">https://www.memphis.= edu/acnl/publications/pdfs/neuroimage2018.pdf</a></span> <o:p></o:p></= p> <p class=3D"MsoNormal">The references therein also cover known sources of A= SSR. The Kuwada article is also a seminal paper to look at. Of course if yo= u're at 40 Hz, you also have to think about brainstem contributions.&n= bsp;<o:p></o:p></p> <p class=3D"MsoNormal"><span style=3D"color:#222222">Kuwada, S., Anderson, = J. S., Batra, R., Fitzpatrick, D. C., Teissier, N., & D'Angelo, W. R. (= 2002). Sources of the scalp-recorded amplitude-modulation following respons= e. <i>Journal of the American Academy of Audiology</i>, <i>13</i>(4), 188-204.= <o:p></o:p></span></p> <p class=3D"MsoListParagraph" style=3D"text-indent:-.25in;mso-list:l2 level= 1 lfo1"><![if !supportLists]><span style=3D"mso-list:Ignore">-<span style= =3D"font:7.0pt "Times New Roman""> &= nbsp; </span></span><![endif]><span style=3D"color:#222222">Gavin Bidelman</span>= <o:p></o:p></p> <p class=3D"MsoNormal">---<o:p></o:p></p> <p class=3D"MsoNormal" style=3D"background:white"><span style=3D"color:blac= k">Not specifically 40 Hz, but plenty of evidence for greater frequency fol= lowing at primary compared to non-primary auditory cortical sites for rates= either side of 40 Hz, e.g. in Fig. 1 in </span><span class=3D"MsoHyperlink"><a href=3D"https://www.jneuros= ci.org/content/39/44/8679">https://www.jneurosci.org/content/39/44/8679</a>= </span><span style=3D"color:black"> or Fig 2. in </span><span cl= ass=3D"MsoHyperlink"><a href=3D"https://pubmed.ncbi.nlm.nih.gov/19675285-co= ding-of-repetitive-transients-by-auditory-cortex-on-heschls-gyrus/">https:/= /pubmed.ncbi.nlm.nih.gov/19675285-coding-of-repetitive-transients-by-audito= ry-cortex-on-heschls-gyrus/</a></span><span style=3D"color:black"><o:p></o:= p></span></p> <p class=3D"MsoListParagraph" style=3D"text-indent:-.25in;mso-list:l2 level= 1 lfo1"><![if !supportLists]><span style=3D"color:black"><span style=3D"mso= -list:Ignore">-<span style=3D"font:7.0pt "Times New Roman""> = ; </span></span></span><![endif]><span style=3D"color:black">Alex Billig<o:p>= </o:p></span></p> <p class=3D"MsoNormal"><span style=3D"color:black">---<o:p></o:p></span></p= > <p><span style=3D"font-family:"Calibri",sans-serif;color:black">T= his work of Luc Arnal is promising and relevant I think, although not exact= ly addressing your issue.<o:p></o:p></span></p> <p><span style=3D"font-family:"Calibri",sans-serif;color:black"><= o:p> </o:p></span></p> <p><span class=3D"MsoHyperlink"><span style=3D"font-family:"Calibri&qu= ot;,sans-serif"><a href=3D"https://www.nature.com/articles/s41467-019-11626= -7">https://www.nature.com/articles/s41467-019-11626-7</a></span></span><sp= an style=3D"font-family:"Calibri",sans-serif;color:black"><o:p></= o:p></span></p> <p><span style=3D"font-family:"Calibri",sans-serif;color:black"><= o:p> </o:p></span></p> <p><span style=3D"font-family:"Calibri",sans-serif;color:black">a= nd also this work from my group (very much neurophysiology based approach)<= o:p></o:p></span></p> <p><span style=3D"font-family:"Calibri",sans-serif;color:black"><= o:p> </o:p></span></p> <p><span class=3D"MsoHyperlink"><span style=3D"font-family:"Calibri&qu= ot;,sans-serif"><a href=3D"https://www.biorxiv.org/content/10.1101/834226v1= ">https://www.biorxiv.org/content/10.1101/834226v1</a></span></span><span s= tyle=3D"font-family:"Calibri",sans-serif;color:black"><o:p></o:p>= </span></p> <p class=3D"MsoNormal"><span style=3D"color:black"><o:p> </o:p></span>= </p> <p class=3D"MsoListParagraph" style=3D"text-indent:-.25in;mso-list:l1 level= 1 lfo2"><![if !supportLists]><span style=3D"color:black"><span style=3D"mso= -list:Ignore">-<span style=3D"font:7.0pt "Times New Roman""> = ; </span></span></span><![endif]><span style=3D"color:black">Danielle Schon<o= :p></o:p></span></p> <p class=3D"MsoNormal"><span style=3D"color:black">---<o:p></o:p></span></p= > <p class=3D"MsoNormal"><span style=3D"color:black">We wrote a paper a few y= ears back looking at the location of 40 Hz ASSRs in Neuroimage.<o:p></o:p><= /span></p> <p class=3D"MsoNormal">Luke, R., De Vos, A., & Wouters, J. (2017). Sour= ce analysis of auditory steady-state responses in acoustic and electric hea= ring. <i>NeuroImage</i>, <i>147</i>, 568-576.<o:p></o:p></p> <p class=3D"MsoNormal"><span style=3D"color:black">I spent quite some time = looking at different methods of analysis, for the 40 Hz ASSR the results we= re very consistent as described in the article regardless of analysis appro= ach (likely due to the high SNR at this modulation rate).<o:p></o:p></span></p> <p class=3D"MsoNormal"><span style=3D"color:black">There is also some addit= ional work from the last author (Prof Jan Wouters) that may be of interest = to you.<o:p></o:p></span></p> <p class=3D"MsoListParagraph" style=3D"text-indent:-.25in;mso-list:l0 level= 1 lfo3"><![if !supportLists]><span style=3D"mso-list:Ignore">-<span style= =3D"font:7.0pt "Times New Roman""> &= nbsp; </span></span><![endif]>Robert Luke<o:p></o:p></p> <p class=3D"MsoNormal">---<o:p></o:p></p> <p class=3D"MsoNormal"><o:p> </o:p></p> <p class=3D"MsoNormal">A few years ago we published a paper on 40-Hz ASSR i= n sedated and anaesthetised infants children (M=FChler et al., 2014).  = ;On the basis of our recordings we concluded that there is a robust brainst= em component also for 40 Hz ASSR. <o:p></o:p></p> <p class=3D"MsoNormal"><span lang=3D"DE">Reference<o:p></o:p></span></p> <p class=3D"MsoNormal"><span lang=3D"DE" style=3D"font-size:10.5pt;line-hei= ght:106%;font-family:AdvOT863180fb;color:black">R M=FChler, T Rahne, K Ment= zel, J L Verhey</span><span lang=3D"DE"> </span><span lang=3D"EN-GB">“40-Hz multiple auditory steady-state res= ponses to narrow-band chirps in sedated and anaesthetized infants”, I= nternational Journal of Pediatric Otorhinolaryngology 78 (2014) 762–7= 68<o:p></o:p></span></p> <p class=3D"MsoListParagraph" style=3D"text-indent:-.25in;mso-list:l0 level= 1 lfo3"><![if !supportLists]><span lang=3D"EN-GB"><span style=3D"mso-list:I= gnore">-<span style=3D"font:7.0pt "Times New Roman""> = </span></span></span><![endif]><span lang=3D"EN-GB">Jesko Verhey<o:p></o:p>= </span></p> <p class=3D"MsoNormal"><span lang=3D"EN-GB"><o:p> </o:p></span></p> <p class=3D"MsoNormal"><span lang=3D"EN-GB">---<o:p></o:p></span></p> <p class=3D"MsoNormal"><span style=3D"color:black">We have one recent paper= <span style=3D"background:white"> - not accepted yet - </span>wit= h B. Morillon and D. Sch=F6n on the topic. With sEEG + MEG, we have sho= wn cortical sources for ~ 60/80 Hz oscillatory responses distributed throughout the cortex : auditory cortex but also up to in= ferior frontal and motor cortical regions (see Figure 1).<o:p></o:p></span>= </p> <p class=3D"MsoNormal"><span style=3D"color:black"><a href=3D"https://www.b= iorxiv.org/content/10.1101/834226v1">https://www.biorxiv.org/content/10.110= 1/834226v1</a><o:p></o:p></span></p> <p class=3D"MsoListParagraph" style=3D"text-indent:-.25in;mso-list:l0 level= 1 lfo3"><![if !supportLists]><span style=3D"color:black"><span style=3D"mso= -list:Ignore">-<span style=3D"font:7.0pt "Times New Roman""> = ; </span></span></span><![endif]><span style=3D"color:black">Jacques Pesnot L= erousseau. <o:p></o:p></span></p> <p class=3D"MsoNormal"><span lang=3D"EN-GB">----<o:p></o:p></span></p> <p class=3D"MsoNormal"> Our two recent papers may be relevant to your = question, though not specifically on this issue. The data suggested that th= e sources are in auditory cortex. <o:p></o:p></p> <p class=3D"MsoNormal">Concurrent temporal channels for auditory processing= : Oscillatory neural entrainment reveals segregation of function at differe= nt scales<o:p></o:p></p> <p class=3D"MsoNormal"><a href=3D"https://journals.plos.org/plosbiology/art= icle?id=3D10.1371%2Fjournal.pbio.2000812">https://journals.plos.org/plosbio= logy/article?id=3D10.1371%2Fjournal.pbio.2000812</a><o:p></o:p></p> <p class=3D"MsoNormal">Theta and Gamma Bands Encode Acoustic Dynamics over = Wide-Ranging Timescales<span style=3D"font-size:24.0pt;line-height:106%"><o= :p></o:p></span></p> <p class=3D"MsoNormal"><a href=3D"https://academic.oup.com/cercor/advance-a= rticle-abstract/doi/10.1093/cercor/bhz263/5637582">https://academic.oup.com= /cercor/advance-article-abstract/doi/10.1093/cercor/bhz263/5637582</a><o:p>= </o:p></p> <p class=3D"MsoNormal"><o:p> </o:p></p> <p class=3D"MsoListParagraph" style=3D"text-indent:-.25in;mso-list:l0 level= 1 lfo3"><![if !supportLists]><span style=3D"mso-list:Ignore">-<span style= =3D"font:7.0pt "Times New Roman""> &= nbsp; </span></span><![endif]>Xiangbin<o:p></o:p></p> <p class=3D"MsoNormal"><o:p> </o:p></p> <p class=3D"MsoNormal"><span lang=3D"EN-GB">End of responses<o:p></o:p></sp= an></p> <p class=3D"MsoNormal"><o:p> </o:p></p> </div> </body> </html> --_000_E06FF38A806E884E9F935E87BFE5694C01425C222Etabvmexdag1mb_--