Subject: [AUDITORY] Postdoctoral Research Position at Washington University in St Louis From: "Lichtenhan, Jeffery" <jlichtenhan@xxxxxxxx> Date: Fri, 4 Dec 2020 22:48:50 +0000--_000_CH2PR02MB69038BCE6B8A82347B11BD0CB5F10CH2PR02MB6903namp_ Content-Type: text/plain; charset="us-ascii" Content-Transfer-Encoding: quoted-printable We are seeking a fulltime postdoctoral researcher to contribute to new and = ongoing experiments in our hearing science laboratory. PhDs, AuDs, or MDs a= re encouraged to apply. Our research addresses questions related to the origins of physiologic meas= urements from the ear. Physiologic measurements of hearing and vestibular f= unction are routinely used in clinics and basic science laboratories. Despi= te progress, there are gaps in knowledge about the cellular and spatial loc= ation in the inner ear where many physiologic measurements originate. For e= xample, elevated hearing thresholds are measured daily in clinics worldwide= , but we do not know exactly which cochlear cell types contribute to the th= reshold measurements or where along the cochlear length the cells are locat= ed. The present goal of our work is to identify the origins of objective me= asurements of hearing to improve their use in understanding the causes of h= earing loss, for differential diagnosis, for treatment monitoring, and for = studying the mechanics of hearing. We use a variety of challenging approaches in a guinea pig model. We can pr= ovide training for surgical techniques even if you do not have any prior su= rgical experience. One approach we use involves ablation of the endolymphat= ic sac to induce endolymphatic hydrops. Another approach we use sequentiall= y delivers drug solutions to finely spaced cochlear regions using gentle pe= rfusions into the cochlear apex. This technique overcomes the losses of dru= g concentrations associated with the classical use of passive, uncontrolled= round window drug delivery. We currently use postmortem histological and i= mmunohistochemistry techniques to image the inner ear, and anticipate using= newer approaches to visualize structures of the intact and live ear. These= approaches are used to addresses long-standing questions of high scientifi= c and clinical interest that still do not have answers: 1) What is the orig= in of the hearing loss and other symptoms that patients with Meniere's dise= ase experience? 2) Where along the cochlea does cochlear amplification and = otoacoustic emissions originate? Your primary role will be to make measurements using our customized data ac= quisition rigs, complete preliminarily analyses, and to participate in writ= ing manuscripts. Studies initiated by you would be highly encouraged. Over = the past seven years we have successfully trained four postdocs (one PhD, t= wo AuDs, and one MD) that have contributed to a total of 10 publications, f= ive manuscripts that have been submitted or are in preparation, and five tr= ainee-initiated grants or awards. Salary will be commiserate with years of = experience, and full health care benefits are provided. The starting date f= or this position can be flexible, but the ideal candidate would be availabl= e March 1, 2021. A minimum commitment of two years is required. The department of Otolaryngology Washington University in St. Louis has a s= trong history of making major contributions to the field of hearing and ves= tibular science. At present, we have over 20 active scientists and an excit= ing atmosphere with a sense of community that mediates productive research.= This advertised position is for the Lichtenhan Laboratory. Collaborating i= nvestigators for our ongoing projects, who you would have the opportunity t= o learn from, are John J. Guinan Jr. PhD (cochlear mechanics), Alec N. Salt= PhD (pharmacokinetics of inner ear drug delivery), Shawn S. Goodman PhD (a= coustics and signal processing), and Craig A. Buchman MD FACS (electrocochl= eography during human ear surgeries). Please send inquires and CVs to Jeffery T. Lichtenhan, PhD: jlichtenhan@xxxxxxxx= tl.edu<mailto:jlichtenhan@xxxxxxxx> ________________________________ The materials in this message are private and may contain Protected Healthc= are Information or other information of a sensitive nature. If you are not = the intended recipient, be advised that any unauthorized use, disclosure, c= opying or the taking of any action in reliance on the contents of this info= rmation is strictly prohibited. If you have received this email in error, p= lease immediately notify the sender via telephone or return mail. --_000_CH2PR02MB69038BCE6B8A82347B11BD0CB5F10CH2PR02MB6903namp_ Content-Type: text/html; charset="us-ascii" Content-Transfer-Encoding: quoted-printable <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-micr= osoft-com:office:office" xmlns:w=3D"urn:schemas-microsoft-com:office:word" = xmlns:m=3D"http://schemas.microsoft.com/office/2004/12/omml" xmlns=3D"http:= //www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3D"Content-Type" content=3D"text/html; charset=3Dus-ascii"= > <meta name=3D"Generator" content=3D"Microsoft Word 15 (filtered medium)"> <style><!-- /* Font Definitions */ @xxxxxxxx {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4;} @xxxxxxxx {font-family:Calibri; panose-1:2 15 5 2 2 2 4 3 2 4;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {margin:0in; margin-bottom:.0001pt; font-size:12.0pt; font-family:"Times New Roman",serif;} a:link, span.MsoHyperlink {mso-style-priority:99; color:#0563C1; text-decoration:underline;} a:visited, span.MsoHyperlinkFollowed {mso-style-priority:99; color:#954F72; text-decoration:underline;} span.EmailStyle17 {mso-style-type:personal-compose; font-family:"Calibri",sans-serif; color:windowtext;} .MsoChpDefault {mso-style-type:export-only; font-family:"Calibri",sans-serif;} @xxxxxxxx WordSection1 {size:8.5in 11.0in; margin:1.0in 1.0in 1.0in 1.0in;} div.WordSection1 {page:WordSection1;} --></style><!--[if gte mso 9]><xml> <o:shapedefaults v:ext=3D"edit" spidmax=3D"1026" /> </xml><![endif]--><!--[if gte mso 9]><xml> <o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"1" /> </o:shapelayout></xml><![endif]--> </head> <body lang=3D"EN-US" link=3D"#0563C1" vlink=3D"#954F72"> <div class=3D"WordSection1"> <p class=3D"MsoNormal" style=3D"margin-bottom:6.0pt"><span style=3D"font-si= ze:11.0pt;font-family:"Calibri",sans-serif">We are seeking a full= time postdoctoral researcher to contribute to new and ongoing experiments i= n our hearing science laboratory. PhDs, AuDs, or MDs are encouraged to apply. <o:p></o:p></span></p> <p class=3D"MsoNormal" style=3D"margin-bottom:6.0pt"><span style=3D"font-si= ze:11.0pt;font-family:"Calibri",sans-serif">Our research addresse= s questions related to the origins of physiologic measurements from the ear= . Physiologic measurements of hearing and vestibular function are routinely used in clinics and basic science laboratories. Des= pite progress, there are gaps in knowledge about the cellular and spatial l= ocation in the inner ear where many physiologic measurements originate. For= example, elevated hearing thresholds are measured daily in clinics worldwide, but we do not know exactly which = cochlear cell types contribute to the threshold measurements or where along= the cochlear length the cells are located. The present goal of our work is= to identify the origins of objective measurements of hearing to improve their use in understanding the causes o= f hearing loss, for differential diagnosis, for treatment monitoring, and f= or studying the mechanics of hearing. <o:p></o:p></span></p> <p class=3D"MsoNormal" style=3D"margin-bottom:6.0pt"><span style=3D"font-si= ze:11.0pt;font-family:"Calibri",sans-serif">We use a variety of c= hallenging approaches in a guinea pig model. We can provide training for su= rgical techniques even if you do not have any prior surgical experience. One approach we use involves ablation of the endolymp= hatic sac to induce endolymphatic hydrops. Another approach we use sequenti= ally delivers drug solutions to finely spaced cochlear regions using gentle= perfusions into the cochlear apex. This technique overcomes the losses of drug concentrations associated with= the classical use of passive, uncontrolled round window drug delivery. We = currently use postmortem histological and immunohistochemistry techniques t= o image the inner ear, and anticipate using newer approaches to visualize structures of the intact and live ear.= These approaches are used to addresses long-standing questions of high sci= entific and clinical interest that still do not have answers: 1) What is th= e origin of the hearing loss and other symptoms that patients with Meniere’s disease experience? 2) W= here along the cochlea does cochlear amplification and otoacoustic emission= s originate? <o:p></o:p></span></p> <p class=3D"MsoNormal" style=3D"margin-bottom:6.0pt"><span style=3D"font-si= ze:11.0pt;font-family:"Calibri",sans-serif">Your primary role wil= l be to make measurements using our customized data acquisition rigs, compl= ete preliminarily analyses, and to participate in writing manuscripts. Studies initiated by you would be highly encouraged. = Over the past seven years we have successfully trained four postdocs (one P= hD, two AuDs, and one MD) that have contributed to a total of 10 publicatio= ns, five manuscripts that have been submitted or are in preparation, and five trainee-initiated grants or awar= ds. Salary will be commiserate with years of experience, and full health ca= re benefits are provided. The starting date for this position can be flexib= le, but the ideal candidate would be available March 1, 2021. A minimum commitment of two years is required.= <o:p></o:p></span></p> <p class=3D"MsoNormal" style=3D"margin-bottom:6.0pt"><span style=3D"font-si= ze:11.0pt;font-family:"Calibri",sans-serif">The department of Oto= laryngology Washington University in St. Louis has a strong history of maki= ng major contributions to the field of hearing and vestibular science. At present, we have over 20 active scientists and an e= xciting atmosphere with a sense of community that mediates productive resea= rch. This advertised position is for the Lichtenhan Laboratory. Collaborati= ng investigators for our ongoing projects, who you would have the opportunity to learn from, are John J. Gu= inan Jr. PhD (cochlear mechanics), Alec N. Salt PhD (pharmacokinetics of in= ner ear drug delivery), Shawn S. Goodman PhD (acoustics and signal processi= ng), and Craig A. Buchman MD FACS (electrocochleography during human ear surgeries). <o:p></o:p></span></p> <p class=3D"MsoNormal" style=3D"margin-bottom:6.0pt"><span style=3D"font-si= ze:11.0pt;font-family:"Calibri",sans-serif">Please send inquires = and CVs to Jeffery T. Lichtenhan, PhD: <a href=3D"mailto:jlichtenhan@xxxxxxxx">jlichtenhan@xxxxxxxx</a><o:p></o:= p></span></p> <p class=3D"MsoNormal"><span style=3D"font-size:11.0pt;font-family:"Ca= libri",sans-serif"><o:p> </o:p></span></p> </div> <span style=3D"font-size:10.0pt;font-family:"Arial","sans-se= rif""><o:p></o:p></span> <p></p> <div></div> <p class=3D"MsoNormal"><o:p> </o:p></p> <div class=3D"MsoNormal" align=3D"center" style=3D"text-align:center"> <hr size=3D"2" width=3D"100%" align=3D"center"> </div> <p class=3D"MsoNormal"><span style=3D"font-size:7.5pt;font-family:"Ari= al","sans-serif";color:gray">The materials in this message a= re private and may contain Protected Healthcare Information or other inform= ation of a sensitive nature. If you are not the intended recipient, be advised that any unauthorized use, disclosure, copying or th= e taking of any action in reliance on the contents of this information is s= trictly prohibited. If you have received this email in error, please immedi= ately notify the sender via telephone or return mail.</span></p> </body> </html> --_000_CH2PR02MB69038BCE6B8A82347B11BD0CB5F10CH2PR02MB6903namp_--