Subject: Re: aspirin and loud noises From: US <"Scharine, Angelique A CIV USARMY ARL "> Date: Wed, 7 May 2014 10:50:21 +0000 List-Archive:<http://lists.mcgill.ca/scripts/wa.exe?LIST=AUDITORY>------=_NextPart_000_000B_01CF69C0.9BCFADF0 Content-Type: text/plain; charset="us-ascii" Content-Transfer-Encoding: 7bit I believe what you want is research into the use of antioxidants to ameliorate and/or prevent hearing loss. Specifically, two antioxidants, acetyl-L-carnitine (ALCAR) and N-L-acetylcysteine (NAC) have been of interest to the military. This is not specifically my area, but a google search for antioxidants and hearing loss prevention should get you started. It is a bit controversial here because of the concern that people will fail to wear hearing protection, thinking that a drug can fix things. That said, there are many who are exposed to such high levels of noise that even hearing protection is not sufficient. A. -----Original Message----- From: AUDITORY - Research in Auditory Perception [mailto:AUDITORY@xxxxxxxx On Behalf Of Dan Stowell Sent: Tuesday, May 06, 2014 6:16 AM To: AUDITORY@xxxxxxxx Subject: aspirin and loud noises Dear all, I have a memory of a talk by Brian Moore, during which I think he mentioned aspirin having a mild protective effect against hearing impairment from acute loud noise. However, I may have misremembered: now that I search the literature, I can't find anything very definitive - and conversely, I find hints that aspirin may long-term mildly contribute to hearing loss (e.g. <http://europepmc.org/articles/PMC2831770>). I find some animal studies pointing in the direction of the factoid I remember <http://www.ncbi.nlm.nih.gov/pubmed/18259079> <http://www.ncbi.nlm.nih.gov/pubmed/16758221>). Can anyone confirm/deny whether such a protective effect is expected? Thanks Dan -- Dan Stowell EPSRC Research Fellow Centre for Digital Music Queen Mary, University of London Mile End Road, London E1 4NS http://c4dm.eecs.qmul.ac.uk/people/dans.htm http://www.mcld.co.uk/ ------=_NextPart_000_000B_01CF69C0.9BCFADF0 Content-Type: application/x-pkcs7-signature; name="smime.p7s" Content-Transfer-Encoding: base64 Content-Disposition: attachment; filename="smime.p7s" MIAGCSqGSIb3DQEHAqCAMIACAQExCzAJBgUrDgMCGgUAMIAGCSqGSIb3DQEHAQAAoIISnzCCA3Aw ggJYoAMCAQICAQUwDQYJKoZIhvcNAQEFBQAwWzELMAkGA1UEBhMCVVMxGDAWBgNVBAoTD1UuUy4g R292ZXJubWVudDEMMAoGA1UECxMDRG9EMQwwCgYDVQQLEwNQS0kxFjAUBgNVBAMTDURvRCBSb290 IENBIDIwHhcNMDQxMjEzMTUwMDEwWhcNMjkxMjA1MTUwMDEwWjBbMQswCQYDVQQGEwJVUzEYMBYG A1UEChMPVS5TLiBHb3Zlcm5tZW50MQwwCgYDVQQLEwNEb0QxDDAKBgNVBAsTA1BLSTEWMBQGA1UE AxMNRG9EIFJvb3QgQ0EgMjCCASIwDQYJKoZIhvcNAQEBBQADggEPADCCAQoCggEBAMAswfaNO6z/ PzzWcb64dCIH7HBBFfyrQOMHqsHD2J/+2kw6vz/I2Ch7SzYBwKxFJcPSDgqPhRhkED0aE3Aqb47X 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