Subject: Re: Function of Cochlear Nucleus cell types From: "Richard F. Lyon" <dicklyon@xxxxxxxx> Date: Wed, 8 Jan 2014 21:34:15 -0800 List-Archive:<http://lists.mcgill.ca/scripts/wa.exe?LIST=AUDITORY>--001a11c3407ccaf86804ef82f5db Content-Type: text/plain; charset=ISO-8859-1 On CN function, the best publications people suggested are: 1. Rhode, William S., and Steven Greenberg. "Physiology of the cochlear nuclei."*The mammalian auditory pathway: Neurophysiology* 2 (1992): 94-152. - http://web.mit.edu/hst.723/www/ThemePapers/CochlearNucleus/Rhode92.pdf 2. Cochlear Nucleus, Eric D Young And Donata Oertel - http://web1.johnshopkins.edu/chb/research/CNSOB.pdf or http://books.google.com/books?id=KBkR8PwU6ewC&pg=PA125 chapter 4 in The Synaptic Organization of the Brain, edited by Gordon M. Shepherd, 5th ed. 2003 3. Wang, Huan, et al. "Auditory information coding by modeled cochlear nucleus neurons." *Journal of computational neuroscience* 30.3 (2011): 529-542. (author Werner Hemmert sent me a copy) several on DCN discrimination of head-related transfer functions (HRTFs), spectral cues used for vertical sound localization. There's a lot more on this topic: 4. Reiss, Lina AJ, and Eric D. Young. "Spectral edge sensitivity in neural circuits of the dorsal cochlear nucleus." *The Journal of neuroscience* 25.14 (2005): 3680-3691. - http://www.jneurosci.org/content/25/14/3680.long 5. May, Bradford J. "Role of the dorsal cochlear nucleus in the sound localization behavior of cats." *Hearing research* 148.1 (2000): 74-87. - http://stuff.mit.edu/afs/athena/course/other/hst.722/OldFiles/www/Topics/DCN/May2000.pdf What's clear is that different cell types in DCN and VCN make several parallel differently processed representations. Getting more specific, there's good info on binaural and monaural localization processing, some on spectral, temporal, and envelope enhancement, etc., but in general it seems to remain rather vague (to me); but I haven't finished reading, so maybe it will get more clear. Several people also shared a bit on not-yet-published ideas; hopefully they'll let us know when the time is right. Dick On Mon, Jan 6, 2014 at 3:02 PM, Richard F. Lyon <dicklyon@xxxxxxxx> wrote: > That's an interesting question, too, Randy, but likely not very related to > cochlear nucleus. > > I've gotten a few pointers so far, and requests to share the results. > I'll do that. > > Dick > > On 1/5/2014 9:25 PM, Richard F. Lyon wrote: > >> I've been trying to understand and summarize what's known or theorized >>> about the function of various cochlear nucleus cell types. There's a lot >>> of info on response patterns to tone bursts, speech, tones in noise, etc., >>> and a lot known about where some of the different cell types are in the CN >>> and where they project to, but I'm having trouble finding much on the "why" >>> or the signal processing function that these different patterns serve. The >>> synchrony-enhancing bushy cells project to the olivary complex, so it makes >>> sense that they are part of the binaural localization function. But what >>> about all the others? Where can I find good theories about these? >>> >>> Dick >>> >>> --001a11c3407ccaf86804ef82f5db Content-Type: text/html; charset=ISO-8859-1 Content-Transfer-Encoding: quoted-printable <div dir=3D"ltr"><div>On CN function, the best publications people suggeste= d are:<br><br>1. <span style=3D"text-indent:0px;letter-spacing:normal;font-= variant:normal;text-align:start;font-style:normal;display:inline!important;= font-weight:normal;float:none;line-height:16.12px;color:rgb(34,34,34);text-= transform:none;font-size:13px;white-space:normal;font-family:Arial,sans-ser= if;word-spacing:0px">Rhode, William S., and Steven Greenberg. "Physiol= ogy of the cochlear nuclei."</span><i style=3D"text-indent:0px;letter-= spacing:normal;font-variant:normal;text-align:start;font-weight:normal;line= -height:16.12px;color:rgb(34,34,34);text-transform:none;font-size:13px;whit= e-space:normal;font-family:Arial,sans-serif;word-spacing:0px">The mammalian= auditory pathway: Neurophysiology</i><span style=3D"text-indent:0px;letter= -spacing:normal;font-variant:normal;text-align:start;font-style:normal;disp= lay:inline!important;font-weight:normal;float:none;line-height:16.12px;colo= r:rgb(34,34,34);text-transform:none;font-size:13px;white-space:normal;font-= family:Arial,sans-serif;word-spacing:0px"><span>=A0</span>2 (1992): 94-152.= - <a href=3D"http://web.mit.edu/hst.723/www/ThemePapers/CochlearNucleus/Rh= ode92.pdf" target=3D"_blank">http://web.mit.edu/hst.723/www/ThemePapers/Coc= hlearNucleus/Rhode92.pdf</a><br> </span><br>2. Cochlear Nucleus, Eric D Young And Donata Oertel - <a href=3D= "http://web1.johnshopkins.edu/chb/research/CNSOB.pdf" target=3D"_blank">htt= p://web1.johnshopkins.edu/chb/research/CNSOB.pdf</a>=A0 or <a href=3D"http:= //books.google.com/books?id=3DKBkR8PwU6ewC&pg=3DPA125">http://books.goo= gle.com/books?id=3DKBkR8PwU6ewC&pg=3DPA125</a><br> </div>chapter 4 in The Synaptic Organization of the Brain, edited by Gordon= M. Shepherd, 5th ed. 2003<br><br><div>3. <span style=3D"text-indent:0px;le= tter-spacing:normal;font-variant:normal;text-align:start;font-style:normal;= display:inline!important;font-weight:normal;float:none;line-height:16.12px;= color:rgb(34,34,34);text-transform:none;font-size:13px;white-space:normal;f= ont-family:Arial,sans-serif;word-spacing:0px">Wang, Huan, et al. "Audi= tory information coding by modeled cochlear nucleus neurons."<span>=A0= </span></span><i style=3D"text-indent:0px;letter-spacing:normal;font-varian= t:normal;text-align:start;font-weight:normal;line-height:16.12px;color:rgb(= 34,34,34);text-transform:none;font-size:13px;white-space:normal;font-family= :Arial,sans-serif;word-spacing:0px">Journal of computational neuroscience</= i><span style=3D"text-indent:0px;letter-spacing:normal;font-variant:normal;= text-align:start;font-style:normal;display:inline!important;font-weight:nor= mal;float:none;line-height:16.12px;color:rgb(34,34,34);text-transform:none;= font-size:13px;white-space:normal;font-family:Arial,sans-serif;word-spacing= :0px"><span>=A0</span>30.3 (2011): 529-542.</span> (author Werner Hemmert s= ent me a copy)<br> <div><div class=3D"gmail_extra"> <br>several on DCN <span style=3D"text-indent:0px;letter-spacing:normal;fon= t-variant:normal;text-align:start;font-style:normal;display:inline!importan= t;font-weight:normal;float:none;line-height:16.12px;color:rgb(34,34,34);tex= t-transform:none;font-size:13px;white-space:normal;font-family:Arial,sans-s= erif;word-spacing:0px">discrimination of head-related transfer functions (H= RTFs), spectral cues used for vertical sound localization.=A0 There's a= lot more on this topic:<br> <br></span>4. <span style=3D"text-indent:0px;letter-spacing:normal;font-var= iant:normal;text-align:start;font-style:normal;display:inline!important;fon= t-weight:normal;float:none;line-height:16.12px;color:rgb(34,34,34);text-tra= nsform:none;font-size:13px;white-space:normal;font-family:Arial,sans-serif;= word-spacing:0px">Reiss, Lina AJ, and Eric D. Young. "Spectral edge se= nsitivity in neural circuits of the dorsal cochlear nucleus."<span>=A0= </span></span><i style=3D"text-indent:0px;letter-spacing:normal;font-varian= t:normal;text-align:start;font-weight:normal;line-height:16.12px;color:rgb(= 34,34,34);text-transform:none;font-size:13px;white-space:normal;font-family= :Arial,sans-serif;word-spacing:0px">The Journal of neuroscience</i><span st= yle=3D"text-indent:0px;letter-spacing:normal;font-variant:normal;text-align= :start;font-style:normal;display:inline!important;font-weight:normal;float:= none;line-height:16.12px;color:rgb(34,34,34);text-transform:none;font-size:= 13px;white-space:normal;font-family:Arial,sans-serif;word-spacing:0px"><spa= n>=A0</span>25.14 (2005): 3680-3691. - <a href=3D"http://www.jneurosci.org/= content/25/14/3680.long" target=3D"_blank">http://www.jneurosci.org/content= /25/14/3680.long</a><br> <br>5. </span><span style=3D"text-indent:0px;letter-spacing:normal;font-var= iant:normal;text-align:start;font-style:normal;display:inline!important;fon= t-weight:normal;float:none;line-height:16.12px;color:rgb(34,34,34);text-tra= nsform:none;font-size:13px;white-space:normal;font-family:Arial,sans-serif;= word-spacing:0px"><span style=3D"text-indent:0px;letter-spacing:normal;font= -variant:normal;text-align:start;font-style:normal;display:inline!important= ;font-weight:normal;float:none;line-height:16.12px;color:rgb(34,34,34);text= -transform:none;font-size:13px;white-space:normal;font-family:Arial,sans-se= rif;word-spacing:0px">May, Bradford J. "Role of the dorsal cochlear nu= cleus in the sound localization behavior of cats."<span>=A0</span></sp= an><i style=3D"text-indent:0px;letter-spacing:normal;font-variant:normal;te= xt-align:start;font-weight:normal;line-height:16.12px;color:rgb(34,34,34);t= ext-transform:none;font-size:13px;white-space:normal;font-family:Arial,sans= -serif;word-spacing:0px">Hearing research</i><span style=3D"text-indent:0px= ;letter-spacing:normal;font-variant:normal;text-align:start;font-style:norm= al;display:inline!important;font-weight:normal;float:none;line-height:16.12= px;color:rgb(34,34,34);text-transform:none;font-size:13px;white-space:norma= l;font-family:Arial,sans-serif;word-spacing:0px"><span>=A0</span>148.1 (200= 0): 74-87. - <a href=3D"http://stuff.mit.edu/afs/athena/course/other/hst.72= 2/OldFiles/www/Topics/DCN/May2000.pdf" target=3D"_blank">http://stuff.mit.e= du/afs/athena/course/other/hst.722/OldFiles/www/Topics/DCN/May2000.pdf</a><= br> <br></span></span></div><div class=3D"gmail_extra"><span style=3D"text-inde= nt:0px;letter-spacing:normal;font-variant:normal;text-align:start;font-styl= e:normal;display:inline!important;font-weight:normal;float:none;line-height= :16.12px;color:rgb(34,34,34);text-transform:none;font-size:13px;white-space= :normal;font-family:Arial,sans-serif;word-spacing:0px"><span style=3D"text-= indent:0px;letter-spacing:normal;font-variant:normal;text-align:start;font-= style:normal;display:inline!important;font-weight:normal;float:none;line-he= ight:16.12px;color:rgb(34,34,34);text-transform:none;font-size:13px;white-s= pace:normal;font-family:Arial,sans-serif;word-spacing:0px">What's clear= is that different cell types in DCN and VCN make several parallel differen= tly processed representations.=A0 Getting more specific, there's good i= nfo on binaural and monaural localization processing, some on spectral, tem= poral, and envelope enhancement, etc., but in general it seems to remain ra= ther vague (to me); but I haven't finished reading, so maybe it will ge= t more clear.<br> <br></span></span></div><div class=3D"gmail_extra"><span style=3D"text-inde= nt:0px;letter-spacing:normal;font-variant:normal;text-align:start;font-styl= e:normal;display:inline!important;font-weight:normal;float:none;line-height= :16.12px;color:rgb(34,34,34);text-transform:none;font-size:13px;white-space= :normal;font-family:Arial,sans-serif;word-spacing:0px"><span style=3D"text-= indent:0px;letter-spacing:normal;font-variant:normal;text-align:start;font-= style:normal;display:inline!important;font-weight:normal;float:none;line-he= ight:16.12px;color:rgb(34,34,34);text-transform:none;font-size:13px;white-s= pace:normal;font-family:Arial,sans-serif;word-spacing:0px">Several people a= lso shared a bit on not-yet-published ideas; hopefully they'll let us k= now when the time is right.<br> </span></span></div><div class=3D"gmail_extra"><span style=3D"text-indent:0= px;letter-spacing:normal;font-variant:normal;text-align:start;font-style:no= rmal;display:inline!important;font-weight:normal;float:none;line-height:16.= 12px;color:rgb(34,34,34);text-transform:none;font-size:13px;white-space:nor= mal;font-family:Arial,sans-serif;word-spacing:0px"><span style=3D"text-inde= nt:0px;letter-spacing:normal;font-variant:normal;text-align:start;font-styl= e:normal;display:inline!important;font-weight:normal;float:none;line-height= :16.12px;color:rgb(34,34,34);text-transform:none;font-size:13px;white-space= :normal;font-family:Arial,sans-serif;word-spacing:0px"><br> </span></span></div><div class=3D"gmail_extra"><span style=3D"text-indent:0= px;letter-spacing:normal;font-variant:normal;text-align:start;font-style:no= rmal;display:inline!important;font-weight:normal;float:none;line-height:16.= 12px;color:rgb(34,34,34);text-transform:none;font-size:13px;white-space:nor= mal;font-family:Arial,sans-serif;word-spacing:0px"><span style=3D"text-inde= nt:0px;letter-spacing:normal;font-variant:normal;text-align:start;font-styl= e:normal;display:inline!important;font-weight:normal;float:none;line-height= :16.12px;color:rgb(34,34,34);text-transform:none;font-size:13px;white-space= :normal;font-family:Arial,sans-serif;word-spacing:0px">Dick<br> <br><br></span></span><br><br><div class=3D"gmail_quote">On Mon, Jan 6, 201= 4 at 3:02 PM, Richard F. Lyon <span dir=3D"ltr"><<a href=3D"mailto:dickl= yon@xxxxxxxx" target=3D"_blank">dicklyon@xxxxxxxx</a>></span> wrote:<br> <blockquote class=3D"gmail_quote" style=3D"margin:0px 0px 0px 0.8ex;border-= left:1px solid rgb(204,204,204);padding-left:1ex"><div class=3D"gmail_extra= "><div><div>That's an interesting question, too, Randy, but likely not = very related to cochlear nucleus.<br> <br></div>I've gotten a few pointers so far, and requests to share the = results.=A0 I'll do that.<br> <br></div>Dick<br><br>On 1/5/2014 9:25 PM, Richard F. Lyon wrote:<br> <div class=3D"gmail_quote"><blockquote class=3D"gmail_quote" style=3D"margi= n:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex= "><div><div><blockquote class=3D"gmail_quote" style=3D"margin:0px 0px 0px 0= .8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"> I've been trying to understand and summarize what's known or theori= zed about the function of various cochlear nucleus cell types. =A0There'= ;s a lot of info on response patterns to tone bursts, speech, tones in nois= e, etc., and a lot known about where some of the different cell types are i= n the CN and where they project to, but I'm having trouble finding much= on the "why" or the signal processing function that these differ= ent patterns serve. =A0The synchrony-enhancing bushy cells project to the o= livary complex, so it makes sense that they are part of the binaural locali= zation function. =A0But what about all the others? Where can I find good th= eories about these?<br> <br> Dick<br> <br> </blockquote> </div></div></blockquote></div></div></blockquote></div></div></div></div><= /div> --001a11c3407ccaf86804ef82f5db--