Subject: Re: two-tone suppression From: David Mountain <dcm(at)BU.EDU> Date: Wed, 21 Sep 2005 11:40:35 -0400Cochlear mechanical nonlinearity is most likely the result of saturation in the outer hair cell mechanical to electrical transduction process. See for example: Mountain DC, Hubbard AE. A piezoelectric model of outer hair cell function. J Acoust Soc Am. 1994 Jan;95(1):350-4. For more info on 2TS and BM mechanics, see the following papers and their references: Rhode WS, Recio A. Multicomponent stimulus interactions observed in basilar-membrane vibration in the basal region of the chinchilla cochlea. J Acoust Soc Am. 2001 Dec;110(6):3140-54. Robles L, Ruggero MA. Mechanics of the mammalian cochlea. Physiol Rev. 2001 Jul;81(3):1305-52. -------------------------------------------------------------------- David C. Mountain, Ph.D. Professor of Biomedical Engineering Boston University 44 Cummington St. Boston, MA 02215 Email: dcm(at)bu.edu Website: http://earlab.bu.edu/external/dcm/ Phone: (617) 353-4343 FAX: (617) 353-6766 Office: ERB 413 On Wed, 21 Sep 2005, Ben Lineton wrote: > Two-tone suppression can also arise from cochlear nonlinearity, as evidenced by mechanical measurements of basilar membrane 2TS (sorry I can't remember the reference), and by measurements of 2TS in otoacoustic emissions (e.g. Brass and Kemp, Suppression of stimulus frequency otoacoustic emissions, J Acoust Soc Am. 1993 Feb;93(2):920-39). > > Put simply, the suppressor tone drives the cochlear amplifier into saturation, so that its response to the probe tone is reduced. > > Ben > > > >>> Martin Braun <nombraun(at)TELIA.COM> 21/09/2005 14:47 >>> > Monita Chatterjee asked: > > > What is the latest on an explanation/model for two-tone suppression? > > These papers may be of use: > > Webster, W.R., Servieére, J., Martin, R., Brown, M., 1985. Uncrossed > and crossed inhibition in the inferior colliculus of the cat: A combined > 2-deoxyglucose and electrophysiological study. J. Neurosci. 5, 1820-1832. > > Palombi, P.S., Caspary, D.M., 1996. GABA inputs control discharge > rate primarily within frequency receptive fields of inferior colliculus > neurons. J. Neurophysiol. 75, 2211-2219. > > Caspary, D.M., Helfert, R.H., Palombi, P.S., 1997. The role of > GABA in shaping frequency response properties in the chinchilla > inferior colliculus. In: Syka, J. (Ed.), Acoustic Signal Processing in > the Central Auditory System. Plenum Press, New York, pp. 227-238. > > > Martin > > ---------------------------- > > Martin Braun > Neuroscience of Music > S-671 95 Klässbol > Sweden > web site: http://w1.570.telia.com/~u57011259/index.htm > >