Subject: Re: two-tone suppression From: Ben Lineton <bl(at)ISVR.SOTON.AC.UK> Date: Wed, 21 Sep 2005 16:21:49 +0100Two-tone suppression can also arise from cochlear nonlinearity, as evidenced by mechanical measurements of basilar membrane 2TS (sorry I can't remember the reference), and by measurements of 2TS in otoacoustic emissions (e.g. Brass and Kemp, Suppression of stimulus frequency otoacoustic emissions, J Acoust Soc Am. 1993 Feb;93(2):920-39). Put simply, the suppressor tone drives the cochlear amplifier into saturation, so that its response to the probe tone is reduced. Ben >>> Martin Braun <nombraun(at)TELIA.COM> 21/09/2005 14:47 >>> Monita Chatterjee asked: > What is the latest on an explanation/model for two-tone suppression? These papers may be of use: Webster, W.R., Servieére, J., Martin, R., Brown, M., 1985. Uncrossed and crossed inhibition in the inferior colliculus of the cat: A combined 2-deoxyglucose and electrophysiological study. J. Neurosci. 5, 1820-1832. Palombi, P.S., Caspary, D.M., 1996. GABA inputs control discharge rate primarily within frequency receptive fields of inferior colliculus neurons. J. Neurophysiol. 75, 2211-2219. Caspary, D.M., Helfert, R.H., Palombi, P.S., 1997. The role of GABA in shaping frequency response properties in the chinchilla inferior colliculus. In: Syka, J. (Ed.), Acoustic Signal Processing in the Central Auditory System. Plenum Press, New York, pp. 227-238. Martin ---------------------------- Martin Braun Neuroscience of Music S-671 95 Klässbol Sweden web site: http://w1.570.telia.com/~u57011259/index.htm