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Hi everyone, Just a reminder that Dr Zheng-Yi Chen will be joining us this Thursday 24th March at 1.00 pm. Please see details below: Dr Zheng-Yi Chen, Associate Professor, Eaton-Peabody Laboratory, Massachusetts
Eye & Ear Infirmary, Harvard Medical School Thursday 24th March at 1.00 pm (UK time):
“Development of genome editing to treat genetic hearing loss”
Abstract:
One in 500 newborns suffer from genetic hearing loss for which cochlear implant is the only treatment option. Recent advance in genome editing CRISPR technology has offered the
opportunity to develop new treatment options by gene editing to correct mutations and to restore hearing in patients. We have been developing genome editing as treatment for genetic hearing loss in two ways. First, we have shown that by a liposomal mediated
ribonucleoproteins (RNP) approach that CRISPR/gRNA complex can be effectively delivered into the mouse inner ear for DNA editing in the hair cells. Second, we used the liposomal-RNP delivery to target genetic mutations in two mouse models of human genetic
hearing loss, one with a mutation in the Tmc1 gene in the inner hair cells and one with a mutation in the Atp2b2 in the outer hair cells. We showed that precise genome editing in each model resulted in rescue of hearing over time. Our approach
elicited minimum off-target effect, a safety concern for the editing-based therapy. We further demonstrate that the editing approach can target two mutations from different genes by a single injection with hearing rescue. Our work laid the foundation for
the development of new treatments for genetic hearing loss in patients.
Biography:
Dr. Zheng-Yi Chen, is an associate professor of the Department of Otolaryngology-Head and Neck Surgery, Harvard
Medical School and Massachusetts Eye & ear Infirmary. He obtained BSc from Sichuan University in China and his DPhil in human genetics from Oxford University, UK. He did his postdoctoral fellowship at the Massachusetts General Hospital/Harvard Medical School.
His laboratory is focused on the development of new treatments for diverse forms of hearing loss including genetic hearing loss, age-related and environmental-related hearing loss.
Their approaches include AAV gene therapy, genome editing and inner ear hair cell regeneration. His laboratory has been involved in identification of numerous genetic deafness genes, editing to treat mouse models of human genetic hearing loss, regeneration
of hair cells in mature mammalian inner ear. Other work includes the creation of pig models for human genetic hearing loss and the development of novel nanoparticle vehicles inner ear delivery.
Details should already be in your calendar, but here is the link in case you want to forward it to colleagues.
Microsoft Teams meeting – Dr Zheng-Yi Chen
Join on your computer or mobile app
Click
here to join the meeting
We look forward to seeing you there.
Best wishes,
Joe
1.00 pm / 13:00 (GMT/Greenwich Mean Time)
2.00 pm / 14:00 (CET/Central European Time)
6.00 am / 06:00 (USA Pacific)
8.00 am / 08:00 (USA Central)
9.00 am / 09:00 (USA Eastern)
09.00 pm / 21:00 (CST/China Standard Time)
Dr Joseph Sollini Auditory Circuits Lab Hearing Sciences Mental Health and Clinical Neuroscience, School of Medicine The University of Nottingham W:
https://www.nottingham.ac.uk/research/groups/hearingsciences/people/joseph.sollini W:
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