Abstract:

In this study, the damage experiments of the living tissue cells (red blood cells and cancer cells) [M. Tamagawa and T. Akamatsu, Proc. 20th Int. Shock Wave Symp., Pasadena, USA, 517--518 (1995)], and the experimental model for cells (microcapsules including dye stuff) by plane shock waves are executed. It is shown from the results that using a microcapsule is an effective method for sensing injury to living tissue cells. To explain these phenomena, the living tissue cells are modeled mathematically as one and two spherical elastic shells filled with liquid toward the shock wave. Using stationary and transient analysis of a spherical shell, the dynamic characteristics of the one living tissue cell and two with a mutual interaction are evaluated. The results show that damage to living tissue cells depends on: (1) the elastic modulus of the cell, (2) the bulk modulus of intracellular material, (3) the thickness of the cell membrane, (4) the distance between the cells on shock-induced damage, and (5) the rise time of the shock wave.